HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: KPCZ (Q05513)
Protein kinase C zeta type (EC 2.7.11.13) (nPKC-zeta)
Gene: PRKCZ

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	11104762
Identification Methods	enzymatic study
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000226 - microtubule cytoskeleton organization GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 592
+	Hs
		529270 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KPCI_HUMAN (1-592): 0: 655: 69.70
+	Hs
		529186 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT2_HUMAN (148-582): 3.96e-153: 450: 36.56
+	Hs
		529185 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT1_HUMAN (172-582): 8.17e-152: 447: 36.85
+	Hs
		529095 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KS6B1_HUMAN (227-590): 7.37e-144: 428: 35.60
+	Hs
		122907 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SGK1_HUMAN (199-583): 1.14e-143: 424: 38.62
+	Hs
		590273 MUC1_HUMAN (39-730): 2.41e-41: 165: 11.50		KPCD_HUMAN (63-585): 8.43e-177: 517: 35.12
+	Hs
		529382 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KS6A3_HUMAN (100-539): 1.13e-110: 349: 18.97
+	Hs
		161418 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		AKT1_HUMAN (172-582): 8.17e-152: 447: 36.85
+	Hs
		529658 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KPCE_HUMAN (6-191): 1.17e-23: 107: 21.00
+	Hs
		436592 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KPCB_HUMAN (85-187): 8.52e-22: 101: 27.18
+	Hs
		529023 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KPCA_HUMAN (101-181): 1.4e-16: 85.3: 29.63
+	Hs
		424623 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		KPCG_HUMAN (116-180): 1.88e-10: 65.9: 36.92
+	Rn
		620044 TAU_RAT (1-758): 3.21e-76: 263: 72.11		KPCB_RAT (85-187): 7.94e-22: 101: 27.18
+	Rn
		98735 F1LST4_RAT (1-757): 7.75e-76: 262: 72.21		KPCB_RAT (85-187): 7.94e-22: 101: 27.18
+	Mm
		530777 TAU_MOUSE (1-758): 8.57e-72: 250: 70.17		KPCG_MOUSE (116-180): 1.8e-10: 65.9: 36.92