HitPredict

Interactor 1: TAU (P10636)
Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)
Gene: MAPT

Interactor 2: BRSK1 (Q8TDC3)
Serine/threonine-protein kinase BRSK1 (EC 2.7.11.1) (Brain-selective kinase 1) (EC 2.7.11.26) (Brain-specific serine/threonine-protein kinase 1) (BR serine/threonine-protein kinase 1) (Serine/threonine-protein kinase SAD-B) (Synapses of Amphids Defective homolog 1) (SAD1 homolog) (hSAD1)
Gene: BRSK1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.63	0.60	0.619

Property	Details
Experiments	21985311, 35063084
Identification Methods	enzymatic study, affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0019901 - protein kinase binding GO:0048167 - regulation of synaptic plasticity
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 758 Hs			1 778
+	Hs
		530051 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		BRSK2_HUMAN (17-778): 3.01e-175: 522: 70.54
+	Hs
		529136 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK3_HUMAN (11-711): 1.25e-166: 501: 26.75
+	Hs
		530003 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK2_HUMAN (9-711): 8.24e-156: 474: 27.00
+	Hs
		530482 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK1_HUMAN (4-711): 7.92e-151: 462: 25.79
+	Hs
		530232 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MARK4_HUMAN (9-711): 5.66e-147: 450: 26.86
+	Hs
		529448 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SIK1_HUMAN (11-568): 2.21e-143: 442: 32.80
+	Hs
		529802 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		MELK_HUMAN (24-665): 1.52e-143: 438: 23.29
+	Hs
		529185 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT1_HUMAN (3-355): 5.16e-143: 430: 26.87
+	Hs
		529186 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		AKT2_HUMAN (9-357): 5.5e-143: 430: 25.00
+	Mm
		631788 MTAP2_MOUSE (26-758): 2.26e-30: 131: 24.41		BRSK2_MOUSE (25-778): 1.36e-176: 526: 71.15
+	Hs
		536317 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK3_HUMAN (11-711): 1.25e-166: 501: 26.75
+	Hs
		536354 MTAP2_HUMAN (16-758): 7.48e-30: 129: 23.42		MARK4_HUMAN (9-711): 5.66e-147: 450: 26.86
+	Hs
		530620 TAU_HUMAN (1-758): 6.41e-90: 300: 100.00		SIK3_HUMAN (18-370): 2.35e-75: 268: 43.34
+	Hs
		698346 MAP4_HUMAN (22-721): 3.01e-10: 66.2: 9.24		MARK4_HUMAN (9-711): 5.66e-147: 450: 26.86
+	Hs
		161418 KMT2D_HUMAN (3-747): 3.75e-09: 62.7: 10.76		AKT1_HUMAN (3-355): 5.16e-143: 430: 26.87