HitPredict

Interactor 1: KIT (P10721)
Mast/stem cell growth factor receptor Kit (SCFR) (EC 2.7.10.1) (Piebald trait protein) (PBT) (Proto-oncogene c-Kit) (Tyrosine-protein kinase Kit) (p145 c-kit) (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (CD antigen CD117)
Gene: KIT

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.692

Property	Details
Experiments	24728074
Identification Methods	pull down, fluorescence polarization spectroscopy
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2
Common GO terms	GO:0005886 - plasma membrane GO:0006954 - inflammatory response GO:0030183 - B cell differentiation GO:0035556 - intracellular signal transduction GO:0042169 - SH2 domain binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 456
+	Hs
		136269 KIT_HUMAN (1-976): 0: 783: 96.33		P85B_HUMAN (129-453): 1.24e-44: 168: 17.05
+	Hs
		532049 KIT_HUMAN (1-976): 0: 783: 96.33		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		148471 KIT_MOUSE (1-975): 0: 753: 79.65		P85B_MOUSE (131-453): 3.38e-43: 163: 16.27
+	Mm
		431450 KIT_MOUSE (1-975): 0: 753: 79.65		P85A_MOUSE (121-453): 4.28e-43: 163: 14.41
+	Hs
		532095 KIT_HUMAN (1-976): 0: 783: 96.33		P55G_HUMAN (327-453): 3.33e-27: 115: 24.41
+	Hs
		532087 KIT_HUMAN (1-976): 0: 783: 96.33		TENS3_HUMAN (10-436): 9.11e-25: 109: 15.25
+	Hs
		532086 KIT_HUMAN (1-976): 0: 783: 96.33		TENS2_HUMAN (45-436): 3.7e-23: 105: 18.06
+	Hs
		532103 KIT_HUMAN (1-976): 0: 783: 96.33		TENS1_HUMAN (18-436): 4.15e-23: 105: 14.61
+	Hs
		699618 FLT3_HUMAN (11-968): 1.26e-166: 515: 29.95		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		787081 FLT3_HUMAN (11-968): 1.26e-166: 515: 29.95		TENS1_HUMAN (18-436): 4.15e-23: 105: 14.61
+	Hs
		136290 FGFR2_HUMAN (8-323): 1.52e-54: 206: 12.83		P85B_HUMAN (129-453): 1.24e-44: 168: 17.05
+	Hs
		641122 FGFR2_HUMAN (8-323): 1.52e-54: 206: 12.83		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		650058 FGFR3_HUMAN (3-310): 7.49e-52: 198: 13.89		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		136292 FGFR4_HUMAN (4-222): 2.09e-23: 108: 14.75		P85B_HUMAN (129-453): 1.24e-44: 168: 17.05
+	Hs
		648427 FGFR4_HUMAN (4-222): 2.09e-23: 108: 14.75		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		136275 FGFR1_HUMAN (4-218): 2.42e-21: 102: 13.12		P85B_HUMAN (129-453): 1.24e-44: 168: 17.05
+	Hs
		541354 FGFR1_HUMAN (4-218): 2.42e-21: 102: 13.12		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		648609 FGFR4_HUMAN (4-222): 2.09e-23: 108: 14.75		P55G_HUMAN (327-453): 3.33e-27: 115: 24.41
+	Hs
		215899 FGFR1_HUMAN (4-218): 2.42e-21: 102: 13.12		SYNJ1_HUMAN (40-436): 8.68e-25: 110: 12.71
+	Hs
		541547 FGFR1_HUMAN (4-218): 2.42e-21: 102: 13.12		TENS2_HUMAN (45-436): 3.7e-23: 105: 18.06