HitPredict

Interactor 1: HLAE (P13747)
HLA class I histocompatibility antigen, alpha chain E (MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen, alpha chain E (sHLA-E)]
Gene: HLA-E

Interactor 2: NKG2C (P26717)
NKG2-C type II integral membrane protein (CD159 antigen-like family member C) (NK cell receptor C) (NKG2-C-activating NK receptor) (CD antigen CD159c)
Gene: KLRC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18083576
Identification Methods	surface plasmon resonance
Interaction Type	physical association

Property	Details
Interacting Pfam domains	C1-set~Lectin_C, Lectin_C~MHC_I
Common GO terms	GO:0002250 - adaptive immune response GO:0005886 - plasma membrane GO:0009897 - external side of plasma membrane GO:0045954 - positive regulation of natural killer cell mediated cytotoxicity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 358 Hs			1 231
+	Hs
		354302 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		NKG2A_HUMAN (1-231): 1.4e-64: 201: 75.11
+	Hs
		570305 HLAG_HUMAN (1-335): 7.83e-150: 427: 76.72		NKG2A_HUMAN (1-231): 1.4e-64: 201: 75.11
+	Hs
		59726 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		KLRG2_HUMAN (108-229): 1.27e-41: 147: 23.58
+	Hs
		533124 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		NKG2A_HUMAN (1-231): 1.4e-64: 201: 75.11
+	Hs
		382559 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC4E_HUMAN (47-229): 3.87e-40: 139: 14.71
+	Hs
		382490 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC4D_HUMAN (53-228): 2.38e-39: 136: 16.83
+	Hs
		382491 HLAA_HUMAN (1-354): 4.3e-168: 474: 78.81		CLC2B_HUMAN (80-231): 4.76e-40: 136: 23.38
+	Hs
		354435 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		KLRD1_HUMAN (69-231): 7.55e-43: 144: 31.98
+	Hs
		354602 HLAB_HUMAN (1-354): 2.45e-151: 432: 77.40		CLC4E_HUMAN (47-229): 3.87e-40: 139: 14.71
+	Hs
		59727 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		KLRG2_HUMAN (108-229): 1.27e-41: 147: 23.58
+	Hs
		488205 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		KLRD1_HUMAN (69-231): 7.55e-43: 144: 31.98
+	Hs
		533144 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		KLRD1_HUMAN (69-231): 7.55e-43: 144: 31.98
+	Hs
		488420 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4E_HUMAN (47-229): 3.87e-40: 139: 14.71
+	Hs
		488317 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC4D_HUMAN (53-228): 2.38e-39: 136: 16.83
+	Hs
		488322 HLAC_HUMAN (1-354): 3.55e-146: 419: 74.65		CLC2B_HUMAN (80-231): 4.76e-40: 136: 23.38
+	Hs
		533155 HLAE_HUMAN (17-358): 2.88e-145: 416: 100.00		CLC2B_HUMAN (80-231): 4.76e-40: 136: 23.38
+	Hs
		673960 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CL12B_HUMAN (109-229): 1.28e-41: 144: 29.77
+	Hs
		673995 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CLC2D_HUMAN (71-229): 7.05e-41: 139: 22.98
+	Hs
		674000 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CLC4E_HUMAN (47-229): 3.87e-40: 139: 14.71
+	Hs
		673971 HLAF_HUMAN (1-345): 2.93e-141: 406: 72.75		CLC2B_HUMAN (80-231): 4.76e-40: 136: 23.38