HitPredict

Interactor 1: LAMC1 (P11047)
Laminin subunit gamma-1 (Laminin B2 chain) (Laminin-1 subunit gamma) (Laminin-10 subunit gamma) (Laminin-11 subunit gamma) (Laminin-2 subunit gamma) (Laminin-3 subunit gamma) (Laminin-4 subunit gamma) (Laminin-6 subunit gamma) (Laminin-7 subunit gamma) (Laminin-8 subunit gamma) (Laminin-9 subunit gamma) (S-laminin subunit gamma) (S-LAM gamma)
Gene: LAMC1

Interactor 2: EGFL7 (Q9UHF1)
Epidermal growth factor-like protein 7 (EGF-like protein 7) (Multiple epidermal growth factor-like domains protein 7) (Multiple EGF-like domains protein 7) (NOTCH4-like protein) (Vascular endothelial statin) (VE-statin) (Zneu1)
Gene: EGFL7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region GO:0007155 - cell adhesion
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1609 Hs			1 273
+	Hs
		535877 LAMC1_HUMAN (1-1609): 0: 1096: 100.00		NELL1_HUMAN (82-180): 4.1e-26: 109: 36.63
+	Hs
		535839 LAMC1_HUMAN (1-1609): 0: 1096: 100.00		NID2_HUMAN (5-272): 9.09e-22: 96.8: 11.42
+	Hs
		535812 LAMC1_HUMAN (1-1609): 0: 1096: 100.00		NID1_HUMAN (60-271): 1.89e-16: 81: 16.46
+	Mm
		384329 LAMC1_MOUSE (1-1609): 0: 1077: 92.60		NID1_MOUSE (60-206): 1.3e-16: 81.4: 18.07
+	Hs
		572704 LAMC3_HUMAN (37-1604): 0: 869: 42.82		NID1_HUMAN (60-271): 1.89e-16: 81: 16.46
+	Dm
		451718 LAMC1_DROME (15-1607): 0: 870: 38.24		NOTCH_DROME (68-172): 2.45e-09: 59.8: 22.32
+	Hs
		462875 LAMB1_HUMAN (273-1560): 2.47e-108: 383: 19.57		NID2_HUMAN (5-272): 9.09e-22: 96.8: 11.42
+	Mm
		1032094 NOTC1_MOUSE (587-1095): 7.67e-57: 220: 14.97		EGFL7_MOUSE (1-272): 1.08e-38: 138: 78.10
+	Hs
		1047772 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Hs
		857580 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		EGFL7_HUMAN (1-273): 3.18e-41: 144: 100.00
+	Hs
		317563 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		SLIT2_HUMAN (59-271): 1.73e-25: 107: 12.29
+	Hs
		452091 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		PROS_HUMAN (24-201): 7.76e-19: 87.9: 19.37
+	Dm
		95089 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		E1JHA6_DROME (2-138): 3.41e-13: 71.4: 12.93
+	Dm
		451712 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		NOTCH_DROME (68-172): 2.45e-09: 59.8: 22.32
+	Dm
		451716 NOTCH_DROME (597-1108): 5.84e-52: 204: 16.35		DL_DROME (53-168): 3.56e-09: 59: 25.58
+	Hs
		1047591 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		NPNT_HUMAN (80-173): 3.93e-11: 64.8: 32.35
+	Hs
		1008015 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857423 NOTC2_HUMAN (267-810): 4.1e-49: 195: 13.12		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57
+	Hs
		857407 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		JAG1_HUMAN (66-168): 2.85e-10: 62.4: 28.57
+	Hs
		857370 NOTC1_HUMAN (291-739): 1.4e-42: 173: 11.86		NOTC1_HUMAN (85-183): 3.37e-09: 59.4: 21.57