HitPredict

Interactor 1: BRAF (P15056)
Serine/threonine-protein kinase B-raf (EC 2.7.11.1) (Proto-oncogene B-Raf) (p94) (v-Raf murine sarcoma viral oncogene homolog B1)
Gene: BRAF

Interactor 2: 1433B (P31946)
14-3-3 protein beta/alpha (Protein 1054) (Protein kinase C inhibitor protein 1) (KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha, N-terminally processed]
Gene: YWHAB

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.96	1.00	0.982

Property	Details
Experiments	28514442, 27034005, 27684187, 31980649, 10931830, 32707033, 17353931, 33961781, 35271311, 36931259, 15324660, 24255178, unassigned2173, 12620389
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, pull down, two hybrid, anti bait coimmunoprecipitation, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	14-3-3~C1_1, 14-3-3~PK_Tyr_Ser-Thr
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 766 Hs			1 246
+	Hs
		542849 BRAF_HUMAN (1-766): 0: 727: 100.00		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		110869 H7C560_HUMAN (1-763): 0: 721: 99.87		1433E_HUMAN (3-243): 4.39e-144: 405: 65.43
+	Hs
		542857 BRAF_HUMAN (1-766): 0: 727: 100.00		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Hs
		110870 H7C560_HUMAN (1-763): 0: 721: 99.87		1433Z_HUMAN (3-244): 1.49e-141: 398: 87.60
+	Gg
		982842 BRAF_CHICK (18-766): 0: 709: 95.08		1433E_CHICK (3-243): 4.39e-144: 405: 65.43
+	Gg
		982836 BRAF_CHICK (18-766): 0: 709: 95.08		1433Z_CHICK (3-244): 7.37e-141: 396: 87.19
+	Gg
		982838 BRAF_CHICK (18-766): 0: 709: 95.08		1433B_CHICK (3-246): 3.72e-141: 396: 97.95
+	Hs
		46556 A0A2R8Y8E0_HUMAN (1-763): 0: 699: 94.89		1433B_HUMAN (1-246): 3.48e-144: 404: 100.00
+	Hs
		542820 BRAF_HUMAN (1-766): 0: 727: 100.00		1433T_HUMAN (3-244): 3.24e-127: 361: 81.82
+	Mm
		655938 BRAF_MOUSE (12-766): 0: 678: 91.94		1433E_MOUSE (3-243): 4.39e-144: 405: 65.43
+	Gg
		982840 BRAF_CHICK (18-766): 0: 709: 95.08		1433T_CHICK (3-244): 5.61e-128: 363: 82.23
+	Hs
		542847 BRAF_HUMAN (1-766): 0: 727: 100.00		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		542868 BRAF_HUMAN (1-766): 0: 727: 100.00		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Gg
		982833 BRAF_CHICK (18-766): 0: 709: 95.08		1433G_CHICK (3-246): 1.03e-109: 317: 75.40
+	Gg
		982837 BRAF_CHICK (18-766): 0: 709: 95.08		Q5ZKJ2_CHICK (4-246): 7.7e-108: 312: 74.90
+	Hs
		542828 BRAF_HUMAN (1-766): 0: 727: 100.00		1433S_HUMAN (3-239): 3.38e-100: 293: 68.62
+	Hs
		46557 A0A2R8Y8E0_HUMAN (1-763): 0: 699: 94.89		1433G_HUMAN (3-246): 1.91e-109: 317: 75.40
+	Hs
		46558 A0A2R8Y8E0_HUMAN (1-763): 0: 699: 94.89		1433F_HUMAN (4-244): 2.7e-107: 311: 75.51
+	Mm
		655936 BRAF_MOUSE (12-766): 0: 678: 91.94		1433G_MOUSE (3-246): 1.91e-109: 317: 75.40
+	Mm
		250867 BRAF_MOUSE (12-766): 0: 678: 91.94		1433S_MOUSE (3-234): 1.38e-97: 286: 68.38