HitPredict

Interactor 1: CDK4 (P11802)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: PP1G (P36873)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: PPP1CC

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	17274640
Identification Methods	antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005730 - nucleolus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0051301 - cell division
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 323
+	Hs
		667594 CDK2_HUMAN (3-301): 2.3e-144: 409: 44.22		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Mm
		989681 CDK2_MOUSE (3-301): 4.45e-135: 387: 37.89		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		667713 CDK2_HUMAN (3-301): 2.3e-144: 409: 44.22		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		443233 CDK1_HUMAN (3-300): 4.42e-129: 370: 42.24		PP1G_HUMAN (1-323): 0: 603: 100.00
+	Mm
		543022 CDK1_MOUSE (3-300): 5.01e-128: 368: 42.24		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		667714 CDK2_HUMAN (3-301): 2.3e-144: 409: 44.22		PP1B_HUMAN (1-322): 0: 560: 86.89
+	Mm
		718973 CDK4_MOUSE (1-299): 2.9e-125: 361: 95.65		PP1G_MOUSE (1-323): 0: 602: 99.69
+	Hs
		443290 CDK1_HUMAN (3-300): 4.42e-129: 370: 42.24		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		549114 CDK4_HUMAN (1-303): 8.01e-128: 367: 100.00		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Hs
		967666 CDK5_HUMAN (3-301): 3.24e-123: 355: 43.09		PP1A_HUMAN (1-323): 0: 579: 90.66
+	Sp
		410433 CDK1_SCHPO (3-297): 1.9e-122: 353: 43.56		PP11_SCHPO (7-322): 0: 555: 82.92
+	Dm
		559038 Q7K306_DROME (5-299): 7.87e-123: 355: 47.12		PP12_DROME (5-303): 0: 551: 93.31
+	Hs
		667754 CDK2_HUMAN (3-301): 2.3e-144: 409: 44.22		PP2AA_HUMAN (8-312): 5.37e-178: 496: 46.08
+	Hs
		994179 CDK6_HUMAN (5-300): 2.26e-126: 365: 70.03		PP2AA_HUMAN (8-312): 5.37e-178: 496: 46.08
+	Dm
		559021 CDK2_DROME (6-295): 8.65e-69: 218: 43.88		PP12_DROME (5-303): 0: 551: 93.31
+	Sc
		602341 PHO85_YEAST (2-295): 1.81e-68: 217: 41.10		PPZ1_YEAST (7-300): 6.33e-148: 433: 67.46