HitPredict

Interactor 1: CDK4 (P30285)
Cyclin-dependent kinase 4 (EC 2.7.11.22) (CRK3) (Cell division protein kinase 4) (PSK-J3)
Gene: CDK4

Interactor 2: PP1G (P63087)
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Gene: Ppp1cc

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.44	0.60	0.515

Property	Details
Experiments	17274640
Identification Methods	affinity chromatography technology, antibody array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005730 - nucleolus GO:0051301 - cell division
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 303 Mm			1 323
+	Hs
		667594 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		PP1G_HUMAN (1-323): 0: 601: 99.69
+	Mm
		989681 CDK2_MOUSE (3-301): 2.58e-136: 391: 37.32		PP1G_MOUSE (1-323): 0: 601: 100.00
+	Hs
		667713 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		PP1A_HUMAN (1-323): 0: 578: 90.66
+	Hs
		443233 CDK1_HUMAN (3-300): 2.26e-130: 374: 42.24		PP1G_HUMAN (1-323): 0: 601: 99.69
+	Mm
		543022 CDK1_MOUSE (3-300): 2.8e-129: 371: 42.24		PP1G_MOUSE (1-323): 0: 601: 100.00
+	Hs
		667714 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		PP1B_HUMAN (1-322): 0: 559: 86.89
+	Hs
		549078 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		PP1G_HUMAN (1-323): 0: 601: 99.69
+	Hs
		443290 CDK1_HUMAN (3-300): 2.26e-130: 374: 42.24		PP1A_HUMAN (1-323): 0: 578: 90.66
+	Hs
		549114 CDK4_HUMAN (1-303): 4.86e-128: 368: 94.72		PP1A_HUMAN (1-323): 0: 578: 90.66
+	Hs
		967666 CDK5_HUMAN (3-301): 6.07e-125: 360: 43.75		PP1A_HUMAN (1-323): 0: 578: 90.66
+	Sp
		410433 CDK1_SCHPO (3-299): 2.35e-124: 358: 42.62		PP11_SCHPO (7-322): 0: 553: 82.92
+	Dm
		559038 Q7K306_DROME (5-299): 1.27e-123: 357: 46.78		PP12_DROME (1-303): 0: 550: 92.41
+	Hs
		667754 CDK2_HUMAN (3-301): 1.28e-145: 412: 43.56		PP2AA_HUMAN (8-312): 1.11e-177: 495: 46.08
+	Hs
		994179 CDK6_HUMAN (5-299): 4.48e-128: 369: 68.58		PP2AA_HUMAN (8-312): 1.11e-177: 495: 46.08
+	Sc
		602341 PHO85_YEAST (2-297): 2.73e-117: 341: 39.16		PPZ1_YEAST (7-300): 6.07e-148: 433: 67.46
+	Dm
		559021 CDK2_DROME (6-295): 1.69e-68: 217: 43.54		PP12_DROME (1-303): 0: 550: 92.41