HitPredict

Interactor 1: PRPS2 (P11908)
Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)
Gene: PRPS2

Interactor 2: KPRA (Q14558)
Phosphoribosyl pyrophosphate synthase-associated protein 1 (PRPP synthase-associated protein 1) (39 kDa phosphoribosypyrophosphate synthase-associated protein) (PAP39)
Gene: PRPSAP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.94 1.00 0.972

The method score is based on:

Property Details
Experiments 9366267, 33961781, 25416956, 26186194, 28514442, 32296183, 31839598, unassigned1304
Identification Methods pull down, affinity chromatography technology, two hybrid, cross-linking study, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti tag coimmunoprecipitation
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pribosyl_synth~Pribosyl_synth, Pribosyl_synth~Pribosyltran_N, Pribosyltran_N~Pribosyltran_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0005737 - cytoplasm
GO:0006015 - 5-phosphoribose 1-diphosphate biosynthetic process
GO:0006139 - nucleobase-containing compound metabolic process
GO:0006164 - purine nucleotide biosynthetic process
Homologous interactions 17

Homologous interactions

Color coding for hit scores

1 318
Hs

1 356
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Hs
+ Hs
+ Hs
+ Dm
+ Dm
+ Dm
+ Ce
+ Ce
+ Ce
+ Sc

Service provided by Combinatics, Japan

Last updated: 11Aug2025