Interactor 1: PRPS1 (P60891)
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)
Gene: PRPS1
Interactor 2: PRPS1 (P60891)
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)
Gene: PRPS1
Species: Homo sapiens
Source: intact
Category: Small-scale
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.93 | 1.00 | 0.968 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 25416956, 16189514, 25910212, 32296183, 25502805, 31515488, unassigned1304 |
| Identification Methods | two hybrid, two hybrid array, two hybrid bait and prey pooling approach, validated two hybrid, two hybrid prey pooling approach, two hybrid pooling approach |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | Pribosyl_synth~Pribosyl_synth, Pribosyl_synth~Pribosyltran_N, Pribosyltran_N~Pribosyltran_N |
| Common GO terms | GO:0000287 - magnesium ion binding GO:0002189 - ribose phosphate diphosphokinase complex GO:0004749 - ribose phosphate diphosphokinase activity GO:0005524 - ATP binding GO:0005737 - cytoplasm and 11 others more... |
| Homologous interactions | 17 |
Homologous interactions
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
