HitPredict

Interactor 1: PRPS2 (P11908)
Ribose-phosphate pyrophosphokinase 2 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase II) (PRS-II)
Gene: PRPS2

Interactor 2: PRPS1 (P60891)
Ribose-phosphate pyrophosphokinase 1 (EC 2.7.6.1) (PPRibP) (Phosphoribosyl pyrophosphate synthase I) (PRS-I)
Gene: PRPS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.96 1.00 0.983

The method score is based on:

Property Details
Experiments 26186194, 28514442, 33961781, 35575683, 38334954, 31839598, 25416956, 26496610, 25910212, 34349018, 31515488, 32814053, unassigned3799
Identification Methods affinity chromatography technology, cross-linking study, two hybrid, two hybrid prey pooling approach, two hybrid array, anti tag coimmunoprecipitation, validated two hybrid, two hybrid bait and prey pooling approach, two hybrid pooling approach
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pribosyl_synth~Pribosyl_synth, Pribosyl_synth~Pribosyltran_N, Pribosyltran_N~Pribosyltran_N
Common GO terms GO:0000287 - magnesium ion binding
GO:0004749 - ribose phosphate diphosphokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 5 others

more...
Homologous interactions 18

Homologous interactions

Color coding for hit scores

1 318
Hs

1 318
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Last updated: 11Aug2025