HitPredict

Interactor 1: FCG2A (P12318)
Low affinity immunoglobulin gamma Fc region receptor II-a (IgG Fc receptor II-a) (CDw32) (Fc-gamma RII-a) (Fc-gamma-RIIa) (FcRII-a) (CD antigen CD32)
Gene: FCGR2A

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.27	0.60	0.408

Property	Details
Experiments	11453982
Identification Methods	unspecified method
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 217
+	Hs
		731818 FCG2C_HUMAN (1-317): 6.88e-78: 242: 85.17		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		593927 FCG2C_HUMAN (1-317): 6.88e-78: 242: 85.17		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		629547 CD22_HUMAN (31-274): 3.12e-30: 122: 15.89		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		987864 KIRR1_HUMAN (29-220): 2.55e-29: 119: 19.90		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Mm
		770697 CD22_MOUSE (28-290): 4.99e-24: 104: 15.51		GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54
+	Hs
		440404 FCG2C_HUMAN (1-317): 6.88e-78: 242: 85.17		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		557130 FCG2C_HUMAN (1-317): 6.88e-78: 242: 85.17		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		439913 FCG3A_HUMAN (16-255): 7.02e-50: 168: 43.03		LCK_HUMAN (3-202): 7.98e-34: 128: 28.44
+	Hs
		463301 FCG2A_HUMAN (1-317): 2.96e-70: 222: 100.00		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		553417 FCERA_HUMAN (20-247): 2.23e-60: 195: 32.02		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Dm
		233626 O44924_DROME (3-317): 3.87e-37: 143: 12.36		ABL_DROME (4-135): 1.01e-22: 97.4: 37.68
+	Hs
		463262 TUTLB_HUMAN (3-316): 4.24e-43: 160: 14.50		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Hs
		557532 TUTLB_HUMAN (3-316): 4.24e-43: 160: 14.50		SRC_HUMAN (161-215): 3.49e-10: 60.8: 31.58
+	Hs
		463845 TUTLB_HUMAN (3-316): 4.24e-43: 160: 14.50		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		463779 ROBO2_HUMAN (1-314): 5.76e-39: 148: 14.61		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		463325 CD22_HUMAN (31-274): 3.12e-30: 122: 15.89		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Hs
		463707 KIRR1_HUMAN (29-220): 2.55e-29: 119: 19.90		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Mm
		683104 FCRL5_MOUSE (4-306): 4.4e-29: 118: 17.03		LYN_MOUSE (96-215): 2.24e-09: 58.5: 18.03
+	Mm
		465768 FCGR1_MOUSE (30-311): 1.08e-27: 112: 18.27		HCK_MOUSE (103-215): 3.03e-10: 61.2: 20.87
+	Hs
		473360 FCGR1_HUMAN (39-278): 1.7e-26: 109: 17.06		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90