HitPredict

Interactor 1: PTN1 (P18031)
Tyrosine-protein phosphatase non-receptor type 1 (EC 3.1.3.48) (Protein-tyrosine phosphatase 1B) (PTP-1B)
Gene: PTPN1

Interactor 2: DDR2 (Q16832)
Discoidin domain-containing receptor 2 (Discoidin domain receptor 2) (EC 2.7.10.1) (CD167 antigen-like family member B) (Discoidin domain-containing receptor tyrosine kinase 2) (Neurotrophic tyrosine kinase, receptor-related 3) (Receptor protein-tyrosine kinase TKT) (Tyrosine-protein kinase TYRO10) (CD antigen CD167b)
Gene: DDR2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 435 Hs			1 855
+	Hs
		573718 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK2_HUMAN (498-850): 2.17e-106: 348: 40.50
+	Hs
		507839 PTN1_HUMAN (1-435): 0: 539: 100.00		FGFR1_HUMAN (505-851): 2.72e-102: 337: 32.49
+	Hs
		384228 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		573716 PTN1_HUMAN (1-435): 0: 539: 100.00		NTRK3_HUMAN (551-849): 3.61e-99: 329: 42.63
+	Hs
		169163 PTN1_HUMAN (1-435): 0: 539: 100.00		MUSK_HUMAN (557-854): 3.25e-98: 327: 39.42
+	Hs
		522755 PTN1_HUMAN (1-435): 0: 539: 100.00		SRC_HUMAN (521-850): 1.38e-97: 316: 31.52
+	Hs
		522754 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		SRC_HUMAN (521-850): 1.38e-97: 316: 31.52
+	Hs
		435529 PTN1_HUMAN (1-435): 0: 539: 100.00		IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13
+	Hs
		411291 PTN1_HUMAN (1-435): 0: 539: 100.00		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		573663 PTN1_HUMAN (1-435): 0: 539: 100.00		ROR2_HUMAN (551-854): 8.47e-56: 209: 38.39
+	Hs
		337339 PTN1_HUMAN (1-435): 0: 539: 100.00		ABL1_HUMAN (557-846): 9.71e-55: 207: 41.03
+	Hs
		384278 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		384743 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		601500 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		FGFR2_HUMAN (522-851): 6.41e-102: 336: 34.42
+	Hs
		384692 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		NTRK1_HUMAN (551-850): 5.06e-101: 333: 42.62
+	Hs
		411290 PTN2_HUMAN (3-435): 3.97e-156: 449: 52.98		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		411297 PTPRB_HUMAN (2-311): 4.08e-124: 398: 34.39		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		411369 PTPRJ_HUMAN (2-301): 3.29e-123: 389: 33.44		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76
+	Hs
		435618 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		IGF1R_HUMAN (535-845): 9.34e-58: 217: 40.13
+	Hs
		411361 PTN12_HUMAN (24-314): 1e-122: 376: 33.55		INSR_HUMAN (511-849): 1.55e-55: 210: 37.76