HitPredict

Interactor 1: APC (P25054)
Adenomatous polyposis coli protein (Protein APC) (Deleted in polyposis 2.5)
Gene: APC

Interactor 2: LIN7C (Q9NUP9)
Protein lin-7 homolog C (Lin-7C) (Mammalian lin-seven protein 3) (MALS-3) (Vertebrate lin-7 homolog 3) (Veli-3)
Gene: LIN7C

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	26186194, 28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0005923 - bicellular tight junction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2843 Hs			1 197
+	Hs
		626254 APC_HUMAN (1-2843): 0: 1316: 100.00		LIN7B_HUMAN (1-196): 4.81e-55: 175: 84.69
+	Hs
		159158 APC_HUMAN (1-2843): 0: 1316: 100.00		CSKP_HUMAN (13-194): 1.3e-30: 119: 20.53
+	Hs
		626115 APC_HUMAN (1-2843): 0: 1316: 100.00		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		626216 APC_HUMAN (1-2843): 0: 1316: 100.00		DLG3_HUMAN (74-164): 2.8e-20: 89.8: 35.42
+	Hs
		626113 APC_HUMAN (1-2843): 0: 1316: 100.00		PTN13_HUMAN (23-196): 2.66e-14: 72.5: 19.43
+	Hs
		626232 APC_HUMAN (1-2843): 0: 1316: 100.00		MAGI1_HUMAN (94-172): 5.41e-10: 60.1: 35.44
+	Rn
		677772 APC_RAT (1-2843): 0: 1222: 89.60		DLG4_RAT (59-195): 2.17e-23: 98.7: 26.76
+	Mm
		1142526 APC_MOUSE (1-2843): 0: 1220: 89.82		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Ce
		105568 APR1_CAEEL (274-1464): 5.62e-115: 399: 16.91		DLG1_CAEEL (42-177): 1.47e-21: 93.3: 22.54
+	Mm
		57254 NACAM_MOUSE (703-2637): 1.09e-53: 211: 8.91		A2AKD7_MOUSE (40-184): 1.21e-30: 118: 26.71
+	Hs
		663994 SRRM2_HUMAN (943-2827): 1.37e-30: 135: 8.96		PTN4_HUMAN (43-187): 5.75e-33: 126: 29.14
+	Hs
		653971 MAP4_HUMAN (2119-2724): 1.19e-29: 131: 15.90		SNTA1_HUMAN (40-186): 6.39e-31: 119: 26.80
+	Hs
		1033912 CIC_HUMAN (722-2643): 2.1e-17: 92.4: 7.79		SNTB2_HUMAN (61-179): 3e-32: 123: 35.25
+	Hs
		654033 MAP4_HUMAN (2119-2724): 1.19e-29: 131: 15.90		SNX27_HUMAN (91-175): 2.59e-12: 66.6: 38.14
+	Hs
		653989 MAP4_HUMAN (2119-2724): 1.19e-29: 131: 15.90		PDZ11_HUMAN (91-175): 4.41e-13: 65.5: 45.35
+	Mm
		1143541 MAP1A_MOUSE (738-2466): 8.19e-18: 93.6: 8.21		DLG4_MOUSE (59-195): 8.13e-24: 99.8: 26.76
+	Hs
		944681 MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68		DLG2_HUMAN (23-196): 1.68e-25: 104: 23.63
+	Hs
		942322 MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68		DLG4_HUMAN (59-195): 2.19e-23: 98.7: 26.76
+	Hs
		944673 MAP1A_HUMAN (907-2836): 5.17e-16: 87.6: 8.68		DLG1_HUMAN (50-178): 8.31e-23: 97.1: 30.60
+	Hs
		1056856 MDC1_HUMAN (1750-2784): 3.28e-21: 104: 11.74		PDZ11_HUMAN (91-175): 4.41e-13: 65.5: 45.35