HitPredict

Interactor 1: MK01 (P28482)
Mitogen-activated protein kinase 1 (MAP kinase 1) (MAPK 1) (EC 2.7.11.24) (ERT1) (Extracellular signal-regulated kinase 2) (ERK-2) (MAP kinase isoform p42) (p42-MAPK) (Mitogen-activated protein kinase 2) (MAP kinase 2) (MAPK 2)
Gene: MAPK1

Interactor 2: DUS1 (P28562)
Dual specificity protein phosphatase 1 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH1) (Mitogen-activated protein kinase phosphatase 1) (MAP kinase phosphatase 1) (MKP-1) (Protein-tyrosine phosphatase CL100)
Gene: DUSP1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	27432908, 31980649, 11278799, 18519678, 10617468, 16286470
Identification Methods	affinity chromatography technology, two hybrid, enzymatic study, pull down, protein kinase assay
Interaction Type	physical association, direct interaction, phosphorylation reaction

Property	Details
Interacting Pfam domains	DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007049 - cell cycle
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 360 Hs			1 367
+	Hs
		647475 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS1_HUMAN (1-367): 4.51e-149: 427: 100.00
+	Hs
		658919 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS4_HUMAN (19-367): 1.45e-126: 370: 64.23
+	Hs
		647563 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS4_HUMAN (19-367): 1.45e-126: 370: 64.23
+	Hs
		659043 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS16_HUMAN (3-363): 8.59e-115: 349: 28.42
+	Hs
		658960 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS5_HUMAN (3-367): 6.39e-112: 333: 41.71
+	Hs
		658962 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS7_HUMAN (9-345): 9.98e-111: 331: 31.23
+	Hs
		658903 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS2_HUMAN (7-313): 1.35e-111: 329: 52.72
+	Mm
		926403 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS2_MOUSE (7-313): 8.69e-110: 325: 54.31
+	Hs
		647595 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS5_HUMAN (3-367): 6.39e-112: 333: 41.71
+	Hs
		647553 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS2_HUMAN (7-313): 1.35e-111: 329: 52.72
+	Hs
		658923 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS8_HUMAN (7-352): 2.27e-100: 311: 30.75
+	Mm
		926439 MK01_MOUSE (10-360): 4.96e-158: 449: 99.72		DUS6_MOUSE (12-335): 2.62e-102: 308: 30.48
+	Rn
		926496 MK01_RAT (10-360): 4.96e-158: 449: 99.72		DUS6_RAT (11-336): 4.08e-101: 305: 29.83
+	Hs
		658961 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS6_HUMAN (11-335): 1.65e-100: 303: 30.11
+	Hs
		647564 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS8_HUMAN (7-352): 2.27e-100: 311: 30.75
+	Hs
		647597 MK03_HUMAN (4-358): 3.09e-154: 440: 85.92		DUS6_HUMAN (11-335): 1.65e-100: 303: 30.11
+	Hs
		659102 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS10_HUMAN (18-332): 2.76e-90: 281: 29.15
+	Hs
		659034 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS9_HUMAN (3-346): 8.53e-91: 279: 28.80
+	Hs
		659006 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		DUS19_HUMAN (177-325): 1.01e-56: 186: 34.90
+	Hs
		659008 MK01_HUMAN (1-360): 2.42e-158: 449: 100.00		STYX_HUMAN (145-345): 2.32e-55: 182: 29.81