HitPredict

Interactor 1: PSA3 (P25788)
Proteasome subunit alpha type-3 (Macropain subunit C8) (Multicatalytic endopeptidase complex subunit C8) (Proteasome component C8) (Proteasome subunit alpha-7) (alpha-7)
Gene: PSMA3

Interactor 2: PSA6 (P60900)
Proteasome subunit alpha type-6 (27 kDa prosomal protein) (PROS-27) (p27K) (Macropain iota chain) (Multicatalytic endopeptidase complex iota chain) (Proteasome iota chain) (Proteasome subunit alpha-1) (alpha-1)
Gene: PSMA6

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.987

The method score is based on:

Property Details
Experiments 25416956, 21516116, 28292943, 32296183, 9451443, 37071682, 28524877, 38334954, 39358380, 31839598, 26414014, 40437099, 9311996, 16169070, 34349018, 17189198, unassigned1304, 17948026
Identification Methods two hybrid, pull down, biochemical, cross-linking study, affinity chromatography technology, validated two hybrid, two hybrid prey pooling approach, two hybrid array, two hybrid pooling approach, anti bait coimmunoprecipitation
Interaction Type direct interaction, association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Proteasome~Proteasome, Proteasome~Proteasome_A_N, Proteasome_A_N~Proteasome_A_N
Common GO terms GO:0000502 - proteasome complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol
and 4 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 255
Hs

1 246
+ Sp
+ Dm
+ Dm
+ Ce
+ Hs
+ Hs
+ Dm
+ Hs
+ Sc
+ Hs
+ Hs
+ Hv
+ Hs
+ Hs
+ Ss
+ Hs
+ Hs
+ Hs
+ Sc
+ Sc

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Last updated: 11Aug2025