HitPredict

Interactor 1: AKT1 (P31749)
RAC-alpha serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase B) (PKB) (Protein kinase B alpha) (PKB alpha) (Proto-oncogene c-Akt) (RAC-PK-alpha)
Gene: AKT1

Interactor 2: ACTS (P68133)
Actin, alpha skeletal muscle (EC 3.6.4.-) (Alpha-actin-1) [Cleaved into: Actin, alpha skeletal muscle, intermediate form]
Gene: ACTA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	23353701, 16568092
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Actin~Pkinase
Common GO terms	GO:0005524 - ATP binding GO:0005829 - cytosol GO:0010628 - positive regulation of gene expression GO:0030027 - lamellipodium
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 480 Hs			1 377
+	Hs
		681764 AKT1_HUMAN (1-480): 0: 586: 100.00		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Mm
		554911 KPCE_MOUSE (53-474): 8.58e-146: 436: 39.53		Q61275_MOUSE (29-377): 0: 723: 99.14
+	Dm
		862563 AKT1_DROME (3-474): 0: 523: 60.37		ACT3_DROME (1-377): 0: 601: 92.84
+	Hs
		566342 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		ACTB_HUMAN (5-377): 0: 604: 93.83
+	Hs
		566351 KPCA_HUMAN (14-477): 1.41e-151: 448: 36.27		ACTG_HUMAN (4-377): 0: 604: 93.85
+	Hs
		408595 KPCB_HUMAN (14-477): 1.15e-148: 441: 36.67		ACTS_HUMAN (1-377): 0: 605: 100.00
+	Hs
		932958 KPCE_HUMAN (53-474): 3.43e-146: 437: 39.77		ACTS_HUMAN (1-377): 0: 605: 100.00
+	Mm
		554888 KPCE_MOUSE (53-474): 8.58e-146: 436: 39.53		ACTB_MOUSE (5-377): 0: 604: 93.83
+	Hs
		616696 KS6B1_HUMAN (132-479): 4.01e-147: 432: 43.75		ACTS_HUMAN (1-377): 0: 605: 100.00
+	Hs
		933067 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		ACTS_HUMAN (1-377): 0: 605: 100.00
+	Hs
		930035 KS6B2_HUMAN (129-479): 4.6e-147: 430: 42.25		ACTG_HUMAN (4-377): 0: 604: 93.85