Interactor 1: P5CR1 (P32322)
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)
Gene: PYCR1

Interactor 2: P5CR1 (P32322)
Pyrroline-5-carboxylate reductase 1, mitochondrial (P5C reductase 1) (P5CR 1) (EC 1.5.1.2)
Gene: PYCR1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.62 1.00 0.789

The method score is based on:

Property Details
Experiments 16730026, 2722838
Identification Methods x-ray crystallography, molecular sieving
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains F420_oxidored~F420_oxidored, F420_oxidored~P5CR_dimer, P5CR_dimer~P5CR_dimer
Common GO terms GO:0004735 - pyrroline-5-carboxylate reductase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006561 - proline biosynthetic process
GO:0034599 - cellular response to oxidative stress
and 3 others

more...

Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 319
Hs

1 319
+ Hs
+ Hs
+ Hs
+ Hs
+ Ce
+ Hs
+ Mm
+ Dm
+ Dm
+ Dm
+ Sc
+ Cj
+ Dm
+ Hp

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Last updated: 15 Jul 2024