HitPredict

Interactor 1: CNTFR (P26992)
Ciliary neurotrophic factor receptor subunit alpha (CNTF receptor subunit alpha) (CNTFR-alpha)
Gene: CNTFR

Interactor 2: GRB2 (P62993)
Growth factor receptor-bound protein 2 (Adapter protein GRB2) (Protein Ash) (SH2/SH3 adapter GRB2)
Gene: GRB2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~fn3
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 372 Hs			1 217
+	Hs
		987884 CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Mm
		821233 CSF3R_MOUSE (2-346): 2.17e-57: 202: 19.37		GRB2_MOUSE (1-217): 5.96e-71: 217: 99.54
+	Hs
		533840 GHR_HUMAN (110-300): 2.29e-42: 158: 18.54		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Mm
		440273 CSF3R_MOUSE (2-346): 2.17e-57: 202: 19.37		LCK_MOUSE (3-202): 5.91e-38: 139: 28.44
+	Hs
		593916 CNTFR_HUMAN (1-356): 1.07e-68: 222: 100.00		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		362168 CNTFR_HUMAN (1-356): 1.07e-68: 222: 100.00		ABL1_HUMAN (4-139): 4.41e-22: 95.5: 35.46
+	Hs
		871470 LEPR_HUMAN (190-301): 5.64e-15: 78.8: 23.68		GRB2_HUMAN (1-217): 1.28e-70: 216: 100.00
+	Hs
		440384 CNTFR_HUMAN (1-356): 1.07e-68: 222: 100.00		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		473464 CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87		HCK_HUMAN (92-215): 4.76e-11: 63.5: 18.90
+	Hs
		463721 CSF3R_HUMAN (4-342): 2.01e-60: 210: 18.87		LYN_HUMAN (129-215): 1.97e-09: 58.5: 22.47
+	Mm
		465769 CSF3R_MOUSE (2-346): 2.17e-57: 202: 19.37		HCK_MOUSE (103-215): 3.03e-10: 61.2: 20.87
+	Hs
		584462 PRLR_HUMAN (106-324): 1.05e-51: 183: 21.68		VAV_HUMAN (2-60): 7.9e-14: 71.6: 42.37
+	Hs
		533825 GHR_HUMAN (110-300): 2.29e-42: 158: 18.54		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		596945 PRLR_HUMAN (106-324): 1.05e-51: 183: 21.68		VAV2_HUMAN (3-56): 4.85e-11: 63.5: 38.18
+	Hs
		249923 NPHN_HUMAN (28-330): 4.07e-39: 150: 19.31		NCK1_HUMAN (5-145): 9.5e-23: 96.3: 33.14
+	Hs
		249920 NPHN_HUMAN (28-330): 4.07e-39: 150: 19.31		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		249921 NPHN_HUMAN (28-330): 4.07e-39: 150: 19.31		YES_HUMAN (71-215): 7.5e-12: 65.8: 16.33
+	Hs
		439967 UFO_HUMAN (1-342): 1.58e-13: 74.1: 15.64		LCK_HUMAN (3-202): 7.98e-34: 128: 28.44
+	Hs
		440539 PTPRS_HUMAN (10-370): 7.14e-19: 90.7: 12.31		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58
+	Hs
		440371 PTPRD_HUMAN (58-341): 1.75e-15: 80.3: 10.10		FYN_HUMAN (161-215): 9.09e-13: 68.5: 31.58