HitPredict

Interactor 1: A0A087WW66 (A0A087WW66)
26S proteasome non-ATPase regulatory subunit 1
Gene: PSMD1

Interactor 2: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	35271311
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008540 - proteasome regulatory particle, base subcomplex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 914 Hs			1 418
+	Hs
		798739 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00
+	Hs
		701 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47
+	Hs
		700 A0A087WW66_HUMAN (1-914): 0: 1236: 100.00		PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26
+	Hs
		913340 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47
+	Hs
		907132 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26
+	Hs
		906907 PSMD1_HUMAN (1-914): 0: 1216: 95.91		PRS4_HUMAN (32-412): 2.96e-120: 358: 49.09
+	At
		221383 PSD1A_ARATH (1-911): 0: 1154: 46.61		PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43
+	At
		1341469 PSD1B_ARATH (1-911): 0: 1140: 46.50		PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43
+	Dm
		1359001 PSMD1_DROME (2-894): 0: 1056: 58.84		Q9V405_DROME (4-418): 6.87e-131: 384: 86.27
+	Dm
		186132 PSMD1_DROME (2-894): 0: 1056: 58.84		PRS8_DROME (38-418): 1.01e-125: 371: 41.73
+	Dm
		1359019 PSMD1_DROME (2-894): 0: 1056: 58.84		Q9W414_DROME (28-417): 9.19e-124: 366: 41.94
+	Dm
		820502 PSMD1_DROME (2-894): 0: 1056: 58.84		PRS4_DROME (7-412): 3.89e-120: 358: 45.59
+	Sp
		251840 RPN2_SCHPO (1-914): 0: 973: 42.15		PRS6B_SCHPO (34-418): 1.74e-136: 397: 73.90
+	Sp
		251844 RPN2_SCHPO (1-914): 0: 973: 42.15		PRS4_SCHPO (43-411): 5.17e-123: 365: 52.41
+	Sc
		693270 RPN2_YEAST (2-914): 0: 919: 38.04		PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82
+	Sc
		693312 RPN2_YEAST (2-914): 0: 919: 38.04		PRS4_YEAST (34-414): 2.92e-124: 368: 50.38
+	Sc
		693337 RPN2_YEAST (2-914): 0: 919: 38.04		PRS10_YEAST (12-418): 2.63e-120: 358: 40.34
+	Hs
		66339 PSMD2_HUMAN (8-712): 0: 704: 20.00		A8K2M0_HUMAN (1-418): 3.22e-139: 406: 100.00
+	Hs
		798648 PSMD2_HUMAN (8-712): 0: 704: 20.00		PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00
+	Hs
		906819 PSMD2_HUMAN (8-712): 0: 704: 20.00		PRS4_HUMAN (32-412): 2.96e-120: 358: 49.09