HitPredict

Interactor 1: EPHA2 (P29317)
Ephrin type-A receptor 2 (EC 2.7.10.1) (Epithelial cell kinase) (Tyrosine-protein kinase receptor ECK)
Gene: EPHA2

Interactor 2: PKHA2 (Q9HB19)
Pleckstrin homology domain-containing family A member 2 (PH domain-containing family A member 2) (Tandem PH domain-containing protein 2) (TAPP-2)
Gene: PLEKHA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	36976175
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 976 Hs			1 425
+	Hs
		1147437 EPHA7_HUMAN (4-974): 0: 1120: 50.15		PKHA1_HUMAN (1-425): 1e-107: 325: 44.21
+	Hs
		931901 EPHA5_HUMAN (11-976): 0: 1115: 51.34		PKHA1_HUMAN (1-425): 1e-107: 325: 44.21
+	Hs
		932137 EPHA4_HUMAN (1-974): 0: 1110: 50.35		PKHA1_HUMAN (1-425): 1e-107: 325: 44.21
+	Hs
		710895 EPHB2_HUMAN (28-973): 0: 1077: 48.29		PKHA1_HUMAN (1-425): 1e-107: 325: 44.21
+	Hs
		331715 EPHA2_HUMAN (1-976): 0: 1124: 100.00		MTMR5_HUMAN (3-298): 1.5e-48: 179: 17.56
+	Hs
		320536 EPHA2_HUMAN (1-976): 0: 1124: 100.00		FARP2_HUMAN (78-329): 3.25e-39: 152: 17.44
+	Hs
		710305 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PKHA7_HUMAN (118-420): 2.44e-37: 146: 16.81
+	Hs
		710499 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PKHA5_HUMAN (118-392): 1.01e-36: 145: 15.05
+	Hs
		1147436 EPHA7_HUMAN (4-974): 0: 1120: 50.15		PKHA5_HUMAN (118-392): 1.01e-36: 145: 15.05
+	Hs
		710371 EPHA2_HUMAN (1-976): 0: 1124: 100.00		DP13B_HUMAN (91-418): 4.17e-35: 139: 13.21
+	Hs
		710581 EPHA2_HUMAN (1-976): 0: 1124: 100.00		PKHA6_HUMAN (140-410): 6.38e-34: 136: 20.51
+	Hs
		931900 EPHA5_HUMAN (11-976): 0: 1115: 51.34		PKHA5_HUMAN (118-392): 1.01e-36: 145: 15.05
+	Hs
		710317 EPHA2_HUMAN (1-976): 0: 1124: 100.00		MPRIP_HUMAN (142-387): 5.76e-33: 133: 15.89
+	Hs
		710894 EPHB2_HUMAN (28-973): 0: 1077: 48.29		PKHA5_HUMAN (118-392): 1.01e-36: 145: 15.05
+	Hs
		181826 EPHB6_HUMAN (28-962): 0: 869: 37.40		PKHA1_HUMAN (1-425): 1e-107: 325: 44.21
+	Hs
		640292 EPHA1_HUMAN (17-967): 0: 947: 49.28		PKHA5_HUMAN (118-392): 1.01e-36: 145: 15.05
+	Hs
		640336 EPHA1_HUMAN (17-967): 0: 947: 49.28		PKHA6_HUMAN (140-410): 6.38e-34: 136: 20.51
+	Hs
		181825 EPHB6_HUMAN (28-962): 0: 869: 37.40		PKHA5_HUMAN (118-392): 1.01e-36: 145: 15.05
+	Hs
		720328 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		PKHA1_HUMAN (1-425): 1e-107: 325: 44.21
+	Hs
		720354 UFO_HUMAN (294-911): 1.96e-144: 454: 24.15		SWP70_HUMAN (199-402): 1.67e-32: 131: 18.22