HitPredict

Interactor 1: PTN6 (P29350)
Tyrosine-protein phosphatase non-receptor type 6 (EC 3.1.3.48) (Hematopoietic cell protein-tyrosine phosphatase) (Protein-tyrosine phosphatase 1C) (PTP-1C) (Protein-tyrosine phosphatase SHP-1) (SH-PTP1)
Gene: PTPN6

Interactor 2: LMTK2 (Q8IWU2)
Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)
Gene: LMTK2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	28065597
Identification Methods	two hybrid, ubiquitin reconstruction
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~Y_phosphatase
Common GO terms	GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 595 Hs			1 1503
+	Hs
		711143 PTN6_HUMAN (1-595): 0: 630: 100.00		LMTK1_HUMAN (14-1500): 0: 707: 29.02
+	Hs
		711131 PTN6_HUMAN (1-595): 0: 630: 100.00		ERBB4_HUMAN (17-748): 2.34e-131: 442: 18.30
+	Hs
		641125 PTN6_HUMAN (1-595): 0: 630: 100.00		FGFR2_HUMAN (33-454): 3.18e-122: 404: 20.52
+	Hs
		362175 PTN6_HUMAN (1-595): 0: 630: 100.00		ABL1_HUMAN (84-931): 8.08e-117: 397: 18.90
+	Hs
		711125 PTN6_HUMAN (1-595): 0: 630: 100.00		FAK2_HUMAN (66-696): 1.74e-117: 396: 17.39
+	Hs
		463360 PTN6_HUMAN (1-595): 0: 630: 100.00		LYN_HUMAN (86-421): 3.37e-109: 358: 22.19
+	Mm
		683088 PTN6_MOUSE (1-595): 0: 613: 94.45		LYN_MOUSE (86-421): 1.34e-109: 359: 22.19
+	Hs
		362172 PTN4_HUMAN (78-519): 6.34e-123: 386: 27.61		ABL1_HUMAN (84-931): 8.08e-117: 397: 18.90
+	Hs
		411420 PTN6_HUMAN (1-595): 0: 630: 100.00		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		362153 PTN1_HUMAN (230-591): 4.63e-127: 382: 29.86		ABL1_HUMAN (84-931): 8.08e-117: 397: 18.90
+	Hs
		439655 PTN6_HUMAN (1-595): 0: 630: 100.00		INSR_HUMAN (93-407): 2.86e-34: 145: 32.82
+	Hs
		465420 PTN6_HUMAN (1-595): 0: 630: 100.00		IGF1R_HUMAN (131-399): 1.23e-33: 144: 33.33
+	Hs
		477212 PTN6_HUMAN (1-595): 0: 630: 100.00		ROS1_HUMAN (122-443): 4.7e-32: 139: 31.56
+	Hs
		711119 PTN6_HUMAN (1-595): 0: 630: 100.00		PTK7_HUMAN (28-403): 9.67e-31: 134: 29.05
+	Hs
		711099 PTN6_HUMAN (1-595): 0: 630: 100.00		ROR1_HUMAN (112-404): 2.35e-29: 129: 28.57
+	Hs
		179596 PTN1_HUMAN (230-591): 4.63e-127: 382: 29.86		MUSK_HUMAN (18-420): 2.44e-110: 373: 23.19
+	Mm
		711231 PTN6_MOUSE (1-595): 0: 613: 94.45		ROS1_MOUSE (153-411): 8.39e-33: 141: 32.61
+	Hs
		411318 PTN1_HUMAN (230-591): 4.63e-127: 382: 29.86		NTRK1_HUMAN (131-410): 1.29e-36: 152: 33.33
+	Hs
		439646 PTN3_HUMAN (118-523): 1.11e-121: 383: 27.70		INSR_HUMAN (93-407): 2.86e-34: 145: 32.82
+	Hs
		439635 PTN1_HUMAN (230-591): 4.63e-127: 382: 29.86		INSR_HUMAN (93-407): 2.86e-34: 145: 32.82