HitPredict

Interactor 1: 1433S (P31947)
14-3-3 protein sigma (Epithelial cell marker protein 1) (Stratifin)
Gene: SFN

Interactor 2: NEK4 (P51957)
Serine/threonine-protein kinase Nek4 (EC 2.7.11.1) (Never in mitosis A-related kinase 4) (NimA-related protein kinase 4) (Serine/threonine-protein kinase 2) (Serine/threonine-protein kinase NRK2)
Gene: NEK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 248 Hs			1 841
+	Hs
		692004 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		MARK3_HUMAN (3-718): 7.26e-149: 457: 19.13
+	Hs
		730714 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		MARK2_HUMAN (3-718): 2e-144: 447: 18.43
+	Hs
		730927 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		MARK1_HUMAN (3-718): 4.47e-140: 436: 17.88
+	Hs
		730658 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		MRCKA_HUMAN (3-780): 5.85e-130: 428: 19.17
+	Hs
		692031 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		MARK3_HUMAN (3-718): 7.26e-149: 457: 19.13
+	Mm
		972206 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK3_MOUSE (3-718): 5.92e-149: 457: 19.92
+	Mm
		972209 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK2_MOUSE (3-718): 5.64e-145: 448: 18.73
+	Hs
		730878 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		SIK2_HUMAN (1-725): 2.13e-129: 411: 16.65
+	Hs
		730912 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		SNRK_HUMAN (6-734): 1.77e-130: 410: 15.35
+	Mm
		972294 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK1_MOUSE (3-718): 5.41e-140: 435: 18.01
+	Hs
		728051 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		AKT1_HUMAN (1-330): 7.87e-131: 401: 23.44
+	Mm
		972253 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		TAOK2_MOUSE (2-835): 2.62e-129: 419: 16.43
+	Mm
		972284 1433E_MOUSE (2-246): 4.43e-146: 410: 60.41		MARK4_MOUSE (3-718): 6e-134: 418: 18.92
+	At
		1379653 14337_ARATH (2-247): 4.37e-147: 413: 58.07		CIPKC_ARATH (3-430): 5.64e-130: 399: 19.50
+	Hs
		728147 1433E_HUMAN (2-246): 4.43e-146: 410: 60.41		AKT1_HUMAN (1-330): 7.87e-131: 401: 23.44
+	Hs
		730602 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		KS6A2_HUMAN (4-323): 2.08e-102: 335: 21.75
+	Hs
		730780 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		NEK11_HUMAN (6-265): 1.07e-60: 219: 43.02
+	Hs
		730721 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		NEK8_HUMAN (3-313): 8.43e-60: 218: 37.14
+	Hs
		730785 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		NEK9_HUMAN (6-330): 1.51e-56: 212: 36.78
+	Hs
		730923 1433S_HUMAN (1-248): 3.5e-158: 440: 100.00		PLK2_HUMAN (6-260): 3.72e-34: 141: 33.98