HitPredict

Interactor 1: MPC2 (P38857)
Mitochondrial pyruvate carrier 2 (MPC2)
Gene: MPC2

Interactor 2: MPC1 (P53157)
Mitochondrial pyruvate carrier 1 (MPC1) (Protein FMP37)
Gene: MPC1

Species: Saccharomyces cerevisiae S288C

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.89	0.60	0.734

Property	Details
Experiments	22628554, 22628558, 30979775, 37238591, 24244496, 25672363
Identification Methods	anti tag coimmunoprecipitation, tandem affinity purification, biochemical, pull down, affinity chromatography technology, cross-linking study, blue native page
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion GO:0005743 - mitochondrial inner membrane GO:0006850 - mitochondrial pyruvate transmembrane transport GO:0050833 - pyruvate transmembrane transporter activity GO:0098800 - inner mitochondrial membrane protein complex
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 129 Sc			1 130
+	Sc
		859713 MPC1_YEAST (1-124): 7e-58: 177: 22.31		MPC1_YEAST (1-130): 8.83e-60: 181: 100.00
+	Sc
		756320 MPC2_YEAST (1-129): 1.6e-64: 193: 100.00		MPC2_YEAST (1-106): 7.89e-42: 136: 25.47
+	Sc
		756324 MPC2_YEAST (1-129): 1.6e-64: 193: 100.00		MPC3_YEAST (1-106): 3.12e-41: 135: 22.64
+	Sc
		859714 MPC1_YEAST (1-124): 7e-58: 177: 22.31		MPC3_YEAST (1-106): 3.12e-41: 135: 22.64
+	Sc
		861385 MPC3_YEAST (1-118): 1.37e-57: 176: 77.97		MPC3_YEAST (1-106): 3.12e-41: 135: 22.64
+	Hs
		316458 MPC2_HUMAN (10-100): 3.24e-44: 142: 48.35		MPC1_HUMAN (8-106): 6.59e-45: 143: 52.53
+	Hs
		316411 MPC2_HUMAN (10-100): 3.24e-44: 142: 48.35		MPC1L_HUMAN (11-118): 1.96e-38: 127: 44.44
+	Hs
		316405 MPC2_HUMAN (10-100): 3.24e-44: 142: 48.35		MPC2_HUMAN (5-112): 7.79e-38: 126: 19.44