HitPredict

Interactor 1: CDK1 (P34556)
Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)
Gene: cdk-1

Interactor 2: CKS1 (Q17868)
Cyclin-dependent kinases regulatory subunit
Gene: cks-1

Species: Caenorhabditis elegans

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	1.00	0.822

Property	Details
Experiments	16343905, 18692475, unassigned701
Identification Methods	affinity chromatography technology, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	CKS~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0019901 - protein kinase binding GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 332 Ce			1 94
+	Hs
		667697 CDK2_HUMAN (19-318): 8.75e-145: 412: 60.00		CKS1_HUMAN (4-81): 3.41e-43: 136: 62.82
+	Hs
		667577 CDK2_HUMAN (19-318): 8.75e-145: 412: 60.00		CKS2_HUMAN (4-81): 3.16e-42: 134: 57.69
+	Hs
		956646 CDK3_HUMAN (19-319): 1.4e-141: 404: 62.46		CKS1_HUMAN (4-81): 3.41e-43: 136: 62.82
+	Hs
		753913 CDK3_HUMAN (19-319): 1.4e-141: 404: 62.46		CKS2_HUMAN (4-81): 3.16e-42: 134: 57.69
+	Hs
		443287 CDK1_HUMAN (19-316): 3.12e-137: 392: 64.77		CKS1_HUMAN (4-81): 3.41e-43: 136: 62.82
+	Hs
		443221 CDK1_HUMAN (19-316): 3.12e-137: 392: 64.77		CKS2_HUMAN (4-81): 3.16e-42: 134: 57.69
+	At
		663937 CDKA1_ARATH (19-315): 6.6e-134: 384: 57.05		CKS2_ARATH (7-85): 2.01e-42: 134: 55.70
+	At
		1180621 CKB12_ARATH (19-320): 1.22e-132: 381: 45.14		CKS2_ARATH (7-85): 2.01e-42: 134: 55.70
+	At
		200085 CDKA1_ARATH (19-315): 6.6e-134: 384: 57.05		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	At
		200096 CKB12_ARATH (19-320): 1.22e-132: 381: 45.14		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	Dm
		660384 CDK1_DROME (19-314): 8.27e-134: 383: 64.87		CKS1_DROME (5-74): 2.87e-40: 128: 62.86
+	Dm
		660412 CDK1_DROME (19-314): 8.27e-134: 383: 64.87		Q9VHN1_DROME (6-73): 1.31e-39: 128: 63.24
+	Hs
		956647 CDK5_HUMAN (19-318): 3.66e-130: 374: 50.50		CKS1_HUMAN (4-81): 3.41e-43: 136: 62.82
+	At
		1320106 CKB21_ARATH (16-318): 2.17e-130: 375: 44.05		CKS2_ARATH (7-85): 2.01e-42: 134: 55.70
+	Hs
		753914 CDK5_HUMAN (19-318): 3.66e-130: 374: 50.50		CKS2_HUMAN (4-81): 3.16e-42: 134: 57.69
+	At
		1320238 CKB22_ARATH (16-318): 3.34e-129: 373: 45.98		CKS2_ARATH (7-85): 2.01e-42: 134: 55.70
+	At
		200105 CKB21_ARATH (16-318): 2.17e-130: 375: 44.05		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	At
		200106 CKB22_ARATH (16-318): 3.34e-129: 373: 45.98		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	At
		200112 CDKD2_ARATH (9-321): 1.25e-128: 372: 41.53		CKS1_ARATH (7-75): 1.22e-40: 130: 62.32
+	Sp
		410432 CDK1_SCHPO (19-316): 8.67e-130: 373: 52.96		CKS1_SCHPO (6-83): 1.15e-36: 121: 42.86