HitPredict

Interactor 1: TCPZ (P40227)
T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (Chaperonin containing T-complex polypeptide 1 subunit 6A) (HTR3) (Tcp20)
Gene: CCT6A

Interactor 2: MEP50 (Q9BQA1)
Methylosome protein WDR77 (Androgen receptor cofactor p44) (Methylosome protein 50) (MEP-50) (WD repeat-containing protein 77) (p44/Mep50)
Gene: WDR77

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 531 Hs			1 342
+	Sc
		761021 TCPZ_YEAST (3-530): 0: 579: 56.75		PFS2_YEAST (78-327): 8.69e-79: 250: 25.69
+	Hs
		1306646 TCPH_HUMAN (2-530): 0: 576: 27.93		MEP50_HUMAN (1-342): 6.74e-81: 251: 100.00
+	At
		1341262 TCPZA_ARATH (3-530): 0: 664: 62.29		PEX7_ARATH (168-333): 1.4e-34: 130: 23.81
+	Hs
		134793 TCPH_HUMAN (2-530): 0: 576: 27.93		PEX7_HUMAN (29-334): 2.89e-68: 218: 22.54
+	Hs
		134769 TCPZ_HUMAN (1-531): 0: 573: 100.00		PEX7_HUMAN (29-334): 2.89e-68: 218: 22.54
+	At
		1226315 TCPZB_ARATH (3-530): 0: 655: 62.29		PEX7_ARATH (168-333): 1.4e-34: 130: 23.81
+	Hs
		1306704 TCPH_HUMAN (2-530): 0: 576: 27.93		NLE1_HUMAN (114-333): 2.06e-53: 184: 18.05
+	Hs
		770968 TCPZ_HUMAN (1-531): 0: 573: 100.00		FBXW7_HUMAN (3-236): 5.23e-43: 159: 14.29
+	Sc
		744619 TCPZ_YEAST (3-530): 0: 579: 56.75		TAF5_YEAST (15-267): 2.96e-38: 146: 14.77
+	Hs
		1240450 TCPH_HUMAN (2-530): 0: 576: 27.93		POC1A_HUMAN (201-341): 1.98e-27: 112: 18.31
+	Hs
		770932 TCPZ_HUMAN (1-531): 0: 573: 100.00		POC1A_HUMAN (201-341): 1.98e-27: 112: 18.31
+	Sc
		761020 TCPZ_YEAST (3-530): 0: 579: 56.75		COPB2_YEAST (15-314): 1.99e-22: 100: 14.47
+	Hs
		1306645 TCPH_HUMAN (2-530): 0: 576: 27.93		TBL1Y_HUMAN (207-337): 6.68e-19: 89.3: 14.38
+	Hs
		903467 TCPH_HUMAN (2-530): 0: 576: 27.93		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		771009 TCPZ_HUMAN (1-531): 0: 573: 100.00		TBL1Y_HUMAN (207-337): 6.68e-19: 89.3: 14.38
+	Hs
		770771 TCPZ_HUMAN (1-531): 0: 573: 100.00		WDR5_HUMAN (247-341): 5.14e-19: 88.2: 19.79
+	Hs
		197078 TCPH_HUMAN (2-530): 0: 576: 27.93		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		196964 TCPZ_HUMAN (1-531): 0: 573: 100.00		PRP4_HUMAN (253-341): 3.86e-10: 62.8: 13.40
+	Hs
		1202777 TCPH_HUMAN (2-530): 0: 576: 27.93		WDR5B_HUMAN (3-106): 2.76e-09: 59.7: 7.90
+	Hs
		770916 TCPZ_HUMAN (1-531): 0: 573: 100.00		WDR5B_HUMAN (3-106): 2.76e-09: 59.7: 7.90