HitPredict

Interactor 1: PI4KA (P42356)
Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)
Gene: PI4KA

Interactor 2: P2RY8 (Q86VZ1)
P2Y purinoceptor 8 (P2Y8)
Gene: P2RY8

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	33961781
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2102 Hs			1 359
+	Hs
		876131 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		PAR2_HUMAN (10-315): 3.78e-82: 257: 35.71
+	Hs
		787637 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		PAR2_HUMAN (10-315): 3.78e-82: 257: 35.71
+	Hs
		1117762 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		P2RY8_HUMAN (1-359): 1.75e-78: 246: 100.00
+	Hs
		723312 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		APJ_HUMAN (14-346): 1.38e-68: 221: 22.97
+	Hs
		723280 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		APJ_HUMAN (14-346): 1.38e-68: 221: 22.97
+	Hs
		723045 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		OPRM_HUMAN (12-356): 5.97e-67: 218: 22.51
+	Hs
		723014 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		OPRM_HUMAN (12-356): 5.97e-67: 218: 22.51
+	Hs
		824703 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		NPY2R_HUMAN (9-348): 4.28e-66: 215: 18.34
+	Hs
		787633 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		NPY2R_HUMAN (9-348): 4.28e-66: 215: 18.34
+	Hs
		126596 Q4LE69_HUMAN (30-2102): 0: 2747: 100.00		P2Y10_HUMAN (30-307): 9.64e-30: 118: 34.46
+	Hs
		126574 PI4KA_HUMAN (30-2102): 0: 2745: 100.00		P2Y10_HUMAN (30-307): 9.64e-30: 118: 34.46
+	Hs
		787363 PK3CB_HUMAN (1555-2099): 3.14e-140: 468: 20.98		CXCR4_HUMAN (23-308): 3.55e-84: 261: 25.26
+	Hs
		822537 PK3CG_HUMAN (1503-2100): 2.11e-134: 453: 19.49		CXCR4_HUMAN (23-308): 3.55e-84: 261: 25.26
+	Mm
		936867 PK3CG_MOUSE (1503-2100): 1.28e-132: 447: 19.81		CXCR4_MOUSE (23-313): 1.15e-83: 259: 23.92
+	Hs
		1030924 ATR_HUMAN (1573-2101): 8.52e-106: 381: 13.13		GPR17_HUMAN (15-331): 1.86e-84: 262: 28.53
+	Hs
		128855 P3C2A_HUMAN (1392-2101): 1.39e-153: 521: 17.98		P2RY6_HUMAN (26-308): 1.22e-29: 117: 31.33
+	Hs
		723038 ATR_HUMAN (1573-2101): 8.52e-106: 381: 13.13		OPRM_HUMAN (12-356): 5.97e-67: 218: 22.51
+	Hs
		126573 PK3CB_HUMAN (1555-2099): 3.14e-140: 468: 20.98		P2Y10_HUMAN (30-307): 9.64e-30: 118: 34.46