HitPredict

Interactor 1: CDC42 (P40793)
Cdc42 homolog (EC 3.6.5.2)
Gene: CDC42

Interactor 2: SYDE (Q9V9S7)
Rho GTPase-activating protein 100F (RhoGAP-100F) (Synapse defective protein 1 homolog) (Protein syd-1 homolog)
Gene: RhoGAP100F

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	29217522
Identification Methods	enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~Ras, Ras~RhoGAP
Common GO terms	GO:0007266 - Rho protein signal transduction GO:0030030 - cell projection organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Dm			1 1866
+	Hs
		269508 RHOQ_HUMAN (4-187): 1.26e-92: 270: 69.57		SRGP2_HUMAN (762-1566): 8.49e-92: 326: 13.88
+	Hs
		67612 RHOQ_HUMAN (4-187): 1.26e-92: 270: 69.57		RHG32_HUMAN (760-1829): 4.41e-86: 316: 15.58
+	Hs
		601322 RHOQ_HUMAN (4-187): 1.26e-92: 270: 69.57		RHG21_HUMAN (585-1827): 1.2e-83: 308: 14.69
+	Hs
		601263 RHOQ_HUMAN (4-187): 1.26e-92: 270: 69.57		RHG05_HUMAN (600-1168): 5.04e-81: 298: 14.82
+	Hs
		67708 RHOJ_HUMAN (2-188): 8.88e-84: 248: 63.64		RHG32_HUMAN (760-1829): 4.41e-86: 316: 15.58
+	Hs
		67650 RAC1_HUMAN (1-191): 6.47e-83: 245: 69.63		RHG32_HUMAN (760-1829): 4.41e-86: 316: 15.58
+	Mm
		988892 RAC1_MOUSE (1-191): 6.47e-83: 245: 69.63		BCR_MOUSE (787-1154): 5.81e-87: 314: 29.72
+	Hs
		1213085 RHOJ_HUMAN (2-188): 8.88e-84: 248: 63.64		RHG21_HUMAN (585-1827): 1.2e-83: 308: 14.69
+	Hs
		1433529 RHOJ_HUMAN (2-188): 8.88e-84: 248: 63.64		RHG35_HUMAN (567-1178): 3.24e-81: 299: 18.68
+	Hs
		1092743 RHOJ_HUMAN (2-188): 8.88e-84: 248: 63.64		RHG05_HUMAN (600-1168): 5.04e-81: 298: 14.82
+	Hs
		601342 RHOQ_HUMAN (4-187): 1.26e-92: 270: 69.57		SYDE1_HUMAN (646-1197): 2.52e-76: 272: 28.89
+	Mm
		988887 RAC1_MOUSE (1-191): 6.47e-83: 245: 69.63		ABR_MOUSE (567-1162): 1.25e-81: 290: 21.00
+	Mm
		988897 RAC1_MOUSE (1-191): 6.47e-83: 245: 69.63		RHG32_MOUSE (760-1855): 1.22e-75: 282: 14.85
+	Mm
		1282996 RHOJ_MOUSE (2-179): 6.68e-84: 248: 65.17		RHG33_MOUSE (915-1346): 1.21e-73: 273: 22.68
+	Hs
		1257042 RHOJ_HUMAN (2-188): 8.88e-84: 248: 63.64		SYDE1_HUMAN (646-1197): 2.52e-76: 272: 28.89
+	Mm
		988896 RAC1_MOUSE (1-191): 6.47e-83: 245: 69.63		CHIO_MOUSE (869-1148): 1.74e-71: 245: 22.65
+	Hs
		601252 RHOQ_HUMAN (4-187): 1.26e-92: 270: 69.57		RHG01_HUMAN (909-1148): 2.64e-59: 213: 25.10
+	Hs
		1061297 RHOJ_HUMAN (2-188): 8.88e-84: 248: 63.64		RHG01_HUMAN (909-1148): 2.64e-59: 213: 25.10
+	Mm
		988885 RAC1_MOUSE (1-191): 6.47e-83: 245: 69.63		RHG01_MOUSE (909-1150): 4.21e-59: 213: 24.90
+	Mm
		988900 RAC1_MOUSE (1-191): 6.47e-83: 245: 69.63		RHG22_MOUSE (864-1202): 5.14e-57: 213: 23.12