HitPredict

Interactor 1: KPCI (P41743)
Protein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Gene: PRKCI

Interactor 2: NEMO (Q9Y6K9)
NF-kappa-B essential modulator (NEMO) (FIP-3) (IkB kinase-associated protein 1) (IKKAP1) (Inhibitor of nuclear factor kappa-B kinase subunit gamma) (I-kappa-B kinase subunit gamma) (IKK-gamma) (IKKG) (IkB kinase subunit gamma) (NF-kappa-B essential modifier)
Gene: IKBKG

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	0.60	0.541

Property	Details
Experiments	21988832
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0051092 - positive regulation of NF-kappaB transcription factor activity
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 596 Hs			1 419
+	Hs
		835726 KPCI_HUMAN (1-596): 0: 723: 100.00		OPTN_HUMAN (67-418): 2.8e-38: 147: 27.25
+	Hs
		1051346 KPCZ_HUMAN (13-596): 0: 650: 69.60		MRCKB_HUMAN (39-356): 2.86e-10: 64.7: 13.60
+	Hs
		1035033 KPCE_HUMAN (42-590): 0: 531: 36.83		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Mm
		312475 AKT1_MOUSE (149-586): 2.79e-152: 448: 35.49		NEMO_MOUSE (1-419): 3.01e-53: 184: 86.64
+	Hs
		728506 AKT1_HUMAN (167-586): 1.82e-151: 446: 37.00		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		587626 KPCE_HUMAN (42-590): 0: 531: 36.83		DESP_HUMAN (45-363): 7.36e-21: 97.8: 15.84
+	Hs
		1458669 KS6B2_HUMAN (245-592): 5.93e-147: 434: 38.64		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Hs
		772751 KPCE_HUMAN (42-590): 0: 531: 36.83		MYH9_HUMAN (11-402): 4.52e-11: 67.3: 9.93
+	Mm
		591040 KPCE_MOUSE (42-590): 1.04e-180: 530: 36.66		MYH6_MOUSE (3-376): 6.46e-10: 63.4: 14.67
+	Mm
		591067 KPCE_MOUSE (42-590): 1.04e-180: 530: 36.66		MYH7_MOUSE (26-376): 1.81e-09: 61.9: 13.24
+	Hs
		728631 AKT2_HUMAN (123-586): 1.24e-152: 449: 34.30		MYO5A_HUMAN (38-342): 1.71e-24: 108: 14.65
+	Hs
		587568 AKT1_HUMAN (167-586): 1.82e-151: 446: 37.00		DESP_HUMAN (45-363): 7.36e-21: 97.8: 15.84
+	Hs
		728066 AKT1_HUMAN (167-586): 1.82e-151: 446: 37.00		MYH9_HUMAN (11-402): 4.52e-11: 67.3: 9.93
+	Hs
		287700 KS6A5_HUMAN (86-540): 1.28e-112: 356: 18.74		ITSN1_HUMAN (24-403): 1.07e-30: 127: 12.15
+	Hs
		1146500 KS6A2_HUMAN (84-565): 1.14e-120: 375: 20.32		MRCKB_HUMAN (39-356): 2.86e-10: 64.7: 13.60
+	Hs
		436761 KPCB_HUMAN (111-229): 6.45e-18: 89.6: 21.28		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Mm
		312487 KPCT_MOUSE (125-216): 2.44e-12: 71.9: 28.26		NEMO_MOUSE (1-419): 3.01e-53: 184: 86.64
+	Hs
		1048300 KPCT_HUMAN (125-216): 2.76e-12: 71.5: 28.26		NEMO_HUMAN (1-419): 1.12e-52: 183: 100.00
+	Dm
		424690 KPC1_DROME (119-222): 6.72e-17: 86.5: 26.55		MYSN_DROME (48-367): 2.19e-10: 65: 19.89