HitPredict

Interactor 1: UB2D1 (P51668)
Ubiquitin-conjugating enzyme E2 D1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D1) (Stimulator of Fe transport) (SFT) (UBC4/5 homolog) (UbcH5) (Ubiquitin carrier protein D1) (Ubiquitin-conjugating enzyme E2(17)KB 1) (Ubiquitin-conjugating enzyme E2-17 kDa 1) (Ubiquitin-protein ligase D1)
Gene: UBE2D1

Interactor 2: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.995

The method score is based on:

Property Details
Experiments 15280377, 25624478, 30017913, 17301054, 19805293, 19240029, 12690203, 15242646, 25888903, 25543083, 24980433, 27106262, 27903893, 28362432, 30244831, 31796886, 31337857, 34634443, 36952348, 37217945 and 22 others

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Identification Methods pull down, two hybrid
Interaction Type direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains UQ_con~zf-C3HC4_3
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000209 - protein polyubiquitination
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
and 7 others

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Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 147
Hs

1 491
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Last updated: 15 Jul 2024