HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: RIN3 (Q8TB24)
Ras and Rab interactor 3 (Ras interaction/interference protein 3)
Gene: RIN3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	25814554, 32552912, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 985
+	Hs
		855887 CRKL_HUMAN (1-303): 1.48e-70: 222: 100.00		Q6NSK7_HUMAN (1-985): 5.42e-173: 529: 89.14
+	Hs
		3238 A0A0S2Z3Q4_HUMAN (3-302): 1.42e-51: 173: 54.89		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		855694 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		855649 CRK_HUMAN (3-302): 1.42e-51: 173: 54.89		Q6NSK7_HUMAN (1-985): 5.42e-173: 529: 89.14
+	Hs
		292853 GRAP2_HUMAN (3-291): 5.54e-38: 138: 14.53		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		1195624 Q4LE43_HUMAN (5-253): 3.15e-28: 116: 16.60		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		619080 PLCG1_HUMAN (5-253): 8.29e-28: 115: 16.60		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		72726 B0LPF3_HUMAN (126-295): 3.56e-23: 96.8: 15.89		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		987787 GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		1347881 ITSN2_HUMAN (73-297): 1.66e-16: 82.1: 16.89		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		73623 B2R6S4_HUMAN (85-196): 2.49e-16: 80.2: 22.81		RIN3_HUMAN (1-985): 0: 555: 100.00
+	Hs
		1237986 ITSN2_HUMAN (73-297): 1.66e-16: 82.1: 16.89		Q6NSK7_HUMAN (1-985): 5.42e-173: 529: 89.14
+	Hs
		594023 NCK1_HUMAN (85-196): 2.66e-16: 80.2: 22.81		Q6NSK7_HUMAN (1-985): 5.42e-173: 529: 89.14
+	Hs
		913651 VAV2_HUMAN (14-180): 4.48e-40: 150: 19.80		GAPD1_HUMAN (75-841): 1.57e-57: 218: 13.77
+	Hs
		176259 GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89		SYNJ2_HUMAN (181-535): 2.14e-27: 122: 16.89
+	Hs
		176277 ITSN2_HUMAN (73-297): 1.66e-16: 82.1: 16.89		SYNJ2_HUMAN (181-535): 2.14e-27: 122: 16.89
+	Hs
		176246 NCK1_HUMAN (85-196): 2.66e-16: 80.2: 22.81		SYNJ2_HUMAN (181-535): 2.14e-27: 122: 16.89
+	Hs
		590268 GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89		MUC1_HUMAN (124-732): 1.45e-20: 100: 11.75
+	Hs
		215914 GRB2_HUMAN (126-295): 3.56e-23: 96.8: 15.89		SYNJ1_HUMAN (23-494): 7.12e-10: 65.6: 7.69
+	Hs
		215903 NCK1_HUMAN (85-196): 2.66e-16: 80.2: 22.81		SYNJ1_HUMAN (23-494): 7.12e-10: 65.6: 7.69