HitPredict

Interactor 1: NOTC1 (P46531)
Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]
Gene: NOTCH1

Interactor 2: DLK1 (P80370)
Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]
Gene: DLK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	EGF~EGF, EGF~EGF_CA, EGF~hEGF
Common GO terms	GO:0005509 - calcium ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2555 Hs			1 383
+	Hs
		857482 NOTC1_HUMAN (20-2555): 0: 1384: 100.00		DLK2_HUMAN (7-245): 1.03e-50: 176: 41.67
+	Hs
		857370 NOTC1_HUMAN (20-2555): 0: 1384: 100.00		NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00
+	Hs
		139646 NOTC1_HUMAN (20-2555): 0: 1384: 100.00		DLL1_HUMAN (71-351): 4.43e-20: 94: 18.73
+	Hs
		857599 NOTC1_HUMAN (20-2555): 0: 1384: 100.00		JAG2_HUMAN (10-244): 8.91e-19: 90.5: 25.81
+	Hs
		857591 NOTC1_HUMAN (20-2555): 0: 1384: 100.00		NOTC3_HUMAN (22-244): 1.95e-17: 86.7: 31.37
+	Hs
		857407 NOTC1_HUMAN (20-2555): 0: 1384: 100.00		JAG1_HUMAN (114-347): 7.46e-17: 84.4: 15.75
+	Mm
		1032083 NOTC1_MOUSE (23-2555): 0: 1358: 90.61		DLL1_MOUSE (71-351): 5.25e-21: 96.7: 19.79
+	Hs
		857423 NOTC1_HUMAN (20-2555): 0: 1384: 100.00		NOTC2_HUMAN (178-341): 1.79e-09: 61.7: 22.89
+	Dm
		95089 NOTCH_DROME (3-1145): 1.13e-161: 562: 33.79		E1JHA6_DROME (52-343): 5.8e-36: 141: 20.07
+	Dm
		451716 NOTCH_DROME (3-1145): 1.13e-161: 562: 33.79		DL_DROME (38-350): 4.64e-24: 105: 20.87
+	Dm
		451712 NOTCH_DROME (3-1145): 1.13e-161: 562: 33.79		NOTCH_DROME (8-297): 1.74e-14: 77.5: 18.77
+	Dm
		451721 NOTCH_DROME (3-1145): 1.13e-161: 562: 33.79		SERR_DROME (65-227): 1.24e-11: 68.6: 31.52
+	Dm
		68582 A8JNM5_DROME (1644-2464): 4.41e-130: 462: 14.41		NOTCH_DROME (8-297): 1.74e-14: 77.5: 18.77
+	Dm
		262782 Q0KIE7_DROME (1889-2550): 2.05e-92: 335: 14.64		TENM_DROME (207-350): 2.04e-15: 80.2: 12.50
+	Hs
		1008030 JAG1_HUMAN (970-1594): 2.07e-66: 250: 23.94		NOTC3_HUMAN (22-244): 1.95e-17: 86.7: 31.37
+	Hs
		857505 ANR44_HUMAN (1998-2520): 1.92e-56: 217: 11.48		NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00
+	Hs
		1008015 JAG1_HUMAN (970-1594): 2.07e-66: 250: 23.94		NOTC2_HUMAN (178-341): 1.79e-09: 61.7: 22.89
+	Hs
		177336 ANR28_HUMAN (1999-2495): 3.31e-58: 223: 14.37		NOTC3_HUMAN (22-244): 1.95e-17: 86.7: 31.37
+	Hs
		177204 ANR28_HUMAN (1999-2495): 3.31e-58: 223: 14.37		NOTC2_HUMAN (178-341): 1.79e-09: 61.7: 22.89