HitPredict

Interactor 1: PLK1 (P53350)
Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)
Gene: PLK1

Interactor 2: CEP97 (Q8IW35)
Centrosomal protein of 97 kDa (Cep97) (Leucine-rich repeat and IQ domain-containing protein 2)
Gene: CEP97

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.667

Property	Details
Experiments	25659891, 32707033, 19596235
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005813 - centrosome GO:0005814 - centriole GO:0005829 - cytosol GO:1901673 - regulation of mitotic spindle assembly
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 603 Hs			1 865
+	Hs
		160650 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		CEP97_HUMAN (1-865): 0: 589: 100.00
+	Ce
		183856 PLK1_CAEEL (22-599): 0: 536: 50.58		O16366_CAEEL (17-499): 2.07e-51: 193: 19.43
+	Hs
		861819 PLK1_HUMAN (1-603): 0: 617: 100.00		CNTRL_HUMAN (70-246): 8.05e-23: 107: 27.47
+	At
		989500 CDPK1_ARATH (1-498): 7.83e-155: 459: 22.09		CLV1_ARATH (1-367): 3.16e-32: 137: 14.04
+	Dm
		332704 PLK4_DROME (58-304): 7.62e-56: 203: 41.04		Q9VQV7_DROME (7-637): 5.64e-74: 260: 28.98
+	Hs
		1071718 KS6A2_HUMAN (1-367): 4.14e-105: 335: 22.43		NISCH_HUMAN (15-141): 2.04e-28: 125: 27.48
+	Hs
		1073471 KS6A1_HUMAN (1-362): 5.61e-109: 345: 24.87		ERBIN_HUMAN (149-540): 2.89e-09: 63.2: 14.46
+	Sc
		419856 SNF1_YEAST (59-336): 1.66e-45: 172: 35.84		SDS22_YEAST (36-205): 5.33e-23: 103: 29.71
+	Hs
		160644 AURKA_HUMAN (28-307): 4.39e-43: 160: 32.17		CNTRL_HUMAN (70-246): 8.05e-23: 107: 27.47
+	Sc
		419763 SNF1_YEAST (59-336): 1.66e-45: 172: 35.84		CYAA_YEAST (36-204): 1.98e-11: 70.2: 24.35