HitPredict

Interactor 1: EPHA4 (P54764)
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)
Gene: EPHA4

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	35384245
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~PK_Tyr_Ser-Thr
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 986 Hs			1 694
+	Hs
		872436 EPHA5_HUMAN (2-986): 0: 1201: 63.67		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665596 EPHB2_HUMAN (30-983): 0: 1169: 58.47		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		665234 EPHA2_HUMAN (27-986): 0: 1059: 50.36		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		1072602 EPHA7_HUMAN (5-986): 0: 1212: 62.37		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		872491 EPHA5_HUMAN (2-986): 0: 1201: 63.67		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		872712 EPHA4_HUMAN (1-986): 0: 1293: 100.00		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		665661 EPHB2_HUMAN (30-983): 0: 1169: 58.47		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		1072603 EPHA7_HUMAN (5-986): 0: 1212: 62.37		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		872492 EPHA5_HUMAN (2-986): 0: 1201: 63.67		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		665662 EPHB2_HUMAN (30-983): 0: 1169: 58.47		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		600673 EPHA1_HUMAN (17-973): 0: 970: 43.87		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		600712 EPHA1_HUMAN (17-973): 0: 970: 43.87		PKHA6_HUMAN (5-495): 5.54e-58: 214: 13.33
+	Hs
		171334 EPHB6_HUMAN (30-984): 0: 909: 40.10		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		171335 EPHB6_HUMAN (30-984): 0: 909: 40.10		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		674415 UFO_HUMAN (268-928): 5.13e-150: 469: 23.72		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		435634 IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		435765 IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47		PKHA5_HUMAN (5-476): 6.15e-67: 240: 13.00
+	Hs
		411498 INSR_HUMAN (284-902): 1.29e-145: 470: 25.00		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		674531 UFO_HUMAN (268-928): 5.13e-150: 469: 23.72		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49
+	Hs
		435768 IGF1R_HUMAN (394-884): 1.97e-137: 447: 29.47		PKHA1_HUMAN (6-156): 1.25e-32: 132: 25.49