HitPredict

Interactor 1: CDK5 (P48609)
Cyclin-dependent kinase 5 homolog (EC 2.7.11.22) (Cell division protein kinase 5)
Gene: CDK5

Interactor 2: Q9VXM1 (Q9VXM1)
LD22957p
Gene: CycD

Species: Drosophila melanogaster

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.34	1.00	0.590

Property	Details
Experiments	14605208
Identification Methods	two hybrid
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Cyclin_C~Pkinase, Cyclin_N~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0051301 - cell division
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 294 Dm			1 481
+	Hs
		573751 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCNB1_HUMAN (5-446): 1.16e-93: 292: 14.96
+	Hs
		573801 CDK3_HUMAN (1-293): 3.8e-143: 406: 56.80		CCNB1_HUMAN (5-446): 1.16e-93: 292: 14.96
+	Hs
		667764 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCNA1_HUMAN (121-438): 1.05e-89: 283: 21.94
+	Hs
		325466 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCNB2_HUMAN (5-434): 3.15e-89: 279: 19.12
+	Rn
		1048464 Q6P751_RAT (1-294): 5.06e-145: 410: 56.42		CCND2_RAT (138-411): 2.11e-90: 278: 37.14
+	Hs
		629061 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCNA2_HUMAN (23-434): 1.34e-85: 271: 19.58
+	Hs
		667568 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCND2_HUMAN (138-408): 1.78e-87: 271: 37.36
+	Hs
		629100 CDK3_HUMAN (1-293): 3.8e-143: 406: 56.80		CCNA2_HUMAN (23-434): 1.34e-85: 271: 19.58
+	Hs
		666939 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCNE1_HUMAN (53-449): 2.63e-83: 264: 15.49
+	Hs
		667569 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCND3_HUMAN (144-407): 6.86e-84: 262: 38.49
+	Mm
		718862 CDK2_MOUSE (1-294): 5.14e-137: 392: 48.98		CCND2_MOUSE (138-407): 7.99e-91: 280: 37.27
+	Mm
		908677 CDK2_MOUSE (1-294): 5.14e-137: 392: 48.98		CCNA2_MOUSE (16-434): 1.09e-88: 279: 18.86
+	Hs
		666973 CDK3_HUMAN (1-293): 3.8e-143: 406: 56.80		CCNE1_HUMAN (53-449): 2.63e-83: 264: 15.49
+	Hs
		718881 CDK3_HUMAN (1-293): 3.8e-143: 406: 56.80		CCND3_HUMAN (144-407): 6.86e-84: 262: 38.49
+	Hs
		664638 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCND1_HUMAN (138-407): 2.37e-76: 243: 36.63
+	Mm
		671888 CDK2_MOUSE (1-294): 5.14e-137: 392: 48.98		CCND1_MOUSE (138-407): 4.77e-83: 260: 36.26
+	Hs
		664708 CDK3_HUMAN (1-293): 3.8e-143: 406: 56.80		CCND1_HUMAN (138-407): 2.37e-76: 243: 36.63
+	Hs
		355336 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		CCNE2_HUMAN (159-296): 2.61e-14: 76.6: 32.86
+	Hs
		667944 CDK2_HUMAN (1-294): 3.64e-145: 411: 56.76		Q8WUE3_HUMAN (159-296): 2.21e-14: 76.6: 32.86
+	Hs
		355344 CDK3_HUMAN (1-293): 3.8e-143: 406: 56.80		CCNE2_HUMAN (159-296): 2.61e-14: 76.6: 32.86