HitPredict

Interactor 1: ACTB (P60709)
Actin, cytoplasmic 1 (EC 3.6.4.-) (Beta-actin) [Cleaved into: Actin, cytoplasmic 1, N-terminally processed]
Gene: ACTB

Interactor 2: SPIR1 (Q08AE8)
Protein spire homolog 1 (Spir-1)
Gene: SPIRE1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	33961781, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0005856 - cytoskeleton GO:0005886 - plasma membrane GO:2000781 - positive regulation of double-strand break repair
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 375 Hs			1 756
+	Hs
		929833 ACTG_HUMAN (1-375): 0: 601: 98.93		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		932118 ACTC_HUMAN (2-375): 0: 592: 94.12		SPIR1_HUMAN (12-756): 0: 1109: 100.00
+	Hs
		891927 ACTB_HUMAN (1-375): 0: 603: 100.00		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Hs
		929947 ACTG_HUMAN (1-375): 0: 601: 98.93		SPIR2_HUMAN (40-738): 0: 884: 41.39
+	Dm
		501524 ACT1_DROME (2-375): 0: 598: 98.13		SPIR_DROME (40-743): 0: 719: 28.87