HitPredict

Interactor 1: GBG4 (P50150)
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4
Gene: GNG4

Interactor 2: GBB4 (Q9HAV0)
Guanine nucleotide-binding protein subunit beta-4 (Transducin beta chain 4)
Gene: GNB4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.697

Property	Details
Experiments	28514442, 33961781, 8636150, 12782285
Identification Methods	affinity chromatography technology, two hybrid, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005834 - heterotrimeric G-protein complex GO:0007186 - G protein-coupled receptor signaling pathway GO:0045202 - synapse GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 75 Hs			1 340
+	Hs
		893551 GBG4_HUMAN (1-75): 1.42e-30: 103: 100.00		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		984064 GBG3_HUMAN (1-75): 7.94e-30: 102: 69.33		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		992433 GBG3_HUMAN (1-75): 7.94e-30: 102: 69.33		GBB4_HUMAN (1-340): 1.1e-109: 324: 100.00
+	Hs
		948052 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GBB2_HUMAN (1-340): 8.23e-110: 325: 90.00
+	Hs
		948081 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GBB4_HUMAN (1-340): 1.1e-109: 324: 100.00
+	Hs
		893550 GBG4_HUMAN (1-75): 1.42e-30: 103: 100.00		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Hs
		983447 GBG3_HUMAN (1-75): 7.94e-30: 102: 69.33		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Hs
		597345 GBG4_HUMAN (1-75): 1.42e-30: 103: 100.00		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Hs
		597353 GBG3_HUMAN (1-75): 7.94e-30: 102: 69.33		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Hs
		948051 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GBB1_HUMAN (1-340): 6.08e-106: 315: 90.88
+	Bt
		983440 GBG2_BOVIN (5-75): 1.22e-28: 99: 77.47		GBB1_BOVIN (1-340): 6.08e-106: 315: 90.88
+	Mm
		983624 GBG2_MOUSE (5-75): 1.22e-28: 99: 77.47		GBB1_MOUSE (1-340): 6.08e-106: 315: 90.88
+	Hs
		597349 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Mm
		712083 GBG4_MOUSE (1-75): 4.9e-30: 102: 98.67		GBB4_MOUSE (1-340): 4.21e-103: 308: 96.77
+	Hs
		597377 GBG8_HUMAN (7-75): 3.46e-25: 90.1: 60.87		GBB3_HUMAN (1-340): 3.74e-105: 313: 79.71
+	Hs
		163623 GBG4_HUMAN (1-75): 1.42e-30: 103: 100.00		GNB5_HUMAN (129-340): 3.22e-42: 152: 22.62
+	Hs
		163629 GBG3_HUMAN (1-75): 7.94e-30: 102: 69.33		GNB5_HUMAN (129-340): 3.22e-42: 152: 22.62
+	Mm
		893586 GBG4_MOUSE (1-75): 4.9e-30: 102: 98.67		GNB5_MOUSE (129-340): 3.25e-42: 152: 23.08
+	Hs
		163627 GBG2_HUMAN (5-75): 1.22e-28: 99: 77.47		GNB5_HUMAN (129-340): 3.22e-42: 152: 22.62
+	Hs
		163657 GBG8_HUMAN (7-75): 3.46e-25: 90.1: 60.87		GNB5_HUMAN (129-340): 3.22e-42: 152: 22.62