HitPredict

Interactor 1: DAPK1 (P53355)
Death-associated protein kinase 1 (DAP kinase 1) (EC 2.7.11.1)
Gene: DAPK1

Interactor 2: SRC8 (Q14247)
Src substrate cortactin (Amplaxin) (Oncogene EMS1)
Gene: CTTN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	32707033
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Ank_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1430 Hs			1 550
+	Hs
		920439 DAPK1_HUMAN (1-1430): 0: 1983: 100.00		SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12
+	Hs
		1124602 MYLK_HUMAN (1-319): 4.99e-76: 281: 44.06		SRC8_HUMAN (1-550): 0: 561: 100.00
+	Hs
		619137 KCC2A_HUMAN (1-383): 5.59e-120: 385: 29.17		PLCG1_HUMAN (212-548): 5.99e-36: 145: 16.53
+	Dm
		1024270 KCC2A_DROME (8-414): 4.54e-119: 384: 29.05		DBNL_DROME (208-549): 6.59e-34: 136: 20.53
+	Hs
		1091730 ANR50_HUMAN (250-749): 5.46e-97: 344: 21.39		MYO1E_HUMAN (165-549): 9.91e-45: 172: 15.01
+	Hs
		1460649 KCC2A_HUMAN (1-383): 5.59e-120: 385: 29.17		DBNL_HUMAN (359-550): 8.25e-32: 129: 32.21
+	Hs
		1110588 KCC2D_HUMAN (2-383): 1.28e-116: 377: 27.94		DBNL_HUMAN (359-550): 8.25e-32: 129: 32.21
+	Mm
		597663 ANK2_MOUSE (253-702): 2.6e-95: 343: 24.34		SPTN1_MOUSE (213-549): 6.82e-34: 139: 14.12
+	Hs
		1030639 ANK2_HUMAN (253-702): 3.18e-95: 342: 24.34		SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12
+	Hs
		1133196 KCC2A_HUMAN (1-383): 5.59e-120: 385: 29.17		LASP1_HUMAN (358-547): 4.31e-13: 71.4: 22.93
+	Hs
		1091395 ANK3_HUMAN (290-662): 8.32e-87: 316: 28.15		SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12
+	Mm
		86327 ANK3_MOUSE (290-662): 2.25e-85: 311: 28.15		B9EKJ1_MOUSE (213-549): 5.53e-34: 140: 14.12
+	Hs
		1110575 KCC2D_HUMAN (2-383): 1.28e-116: 377: 27.94		ABI2_HUMAN (396-547): 4.13e-13: 73.7: 29.68
+	Hs
		177302 ANR28_HUMAN (259-785): 5.71e-87: 309: 18.60		SH3G3_HUMAN (365-549): 5.48e-31: 125: 18.82
+	Mm
		109257 ANK3_MOUSE (290-662): 2.25e-85: 311: 28.15		ABI2_MOUSE (332-547): 9.93e-13: 72.1: 20.72
+	Mm
		60053 KALRN_MOUSE (2-312): 1.13e-61: 236: 38.91		B9EKJ1_MOUSE (213-549): 5.53e-34: 140: 14.12
+	Hs
		238815 KALRN_HUMAN (2-312): 7.31e-62: 236: 39.23		SPTN1_HUMAN (213-549): 8.25e-34: 139: 14.12
+	Mm
		60071 KALRN_MOUSE (2-312): 1.13e-61: 236: 38.91		SPTN1_MOUSE (213-549): 6.82e-34: 139: 14.12
+	Hs
		299586 TRIO_HUMAN (6-323): 4.13e-59: 227: 38.68		ITSN2_HUMAN (398-548): 1.25e-18: 92.3: 17.88
+	Hs
		943926 RIPK4_HUMAN (635-957): 4.75e-28: 124: 13.99		MYO1E_HUMAN (165-549): 9.91e-45: 172: 15.01