HitPredict

Interactor 1: TPM4 (P67936)
Tropomyosin alpha-4 chain (TM30p1) (Tropomyosin-4)
Gene: TPM4

Interactor 2: PDLI7 (Q9NR12)
PDZ and LIM domain protein 7 (LIM mineralization protein) (LMP) (Protein enigma)
Gene: PDLIM7

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001725 - stress fiber GO:0005829 - cytosol GO:0005925 - focal adhesion
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 248 Hs			1 457
+	Hs
		451318 TPM1_HUMAN (4-248): 1.43e-48: 163: 68.16		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		110806 H7BYY1_HUMAN (1-248): 8.1e-49: 162: 77.82		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		419055 TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Hs
		434438 TPM2_HUMAN (4-248): 5.04e-42: 146: 69.39		PDLI7_HUMAN (1-457): 2.02e-91: 286: 100.00
+	Mm
		886037 TPM1_MOUSE (4-248): 1.11e-48: 163: 68.57		PDLI5_MOUSE (1-282): 2.11e-28: 120: 24.47
+	Mm
		886046 TPM2_MOUSE (4-248): 5.85e-42: 146: 69.39		PDLI5_MOUSE (1-282): 2.11e-28: 120: 24.47
+	Hs
		434422 TPM2_HUMAN (4-248): 5.04e-42: 146: 69.39		PDLI5_HUMAN (1-282): 6.17e-28: 118: 24.82
+	Hs
		434336 TPM2_HUMAN (4-248): 5.04e-42: 146: 69.39		ZN250_HUMAN (362-457): 4.28e-23: 103: 6.25
+	Hs
		418964 TPM3_HUMAN (4-248): 6.47e-47: 159: 69.39		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42
+	Hs
		932007 TPM4_HUMAN (1-248): 5.49e-47: 158: 100.00		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42
+	Hs
		1076422 Q5VU62_HUMAN (91-248): 4.79e-45: 150: 76.58		TRIP6_HUMAN (396-457): 6.89e-09: 59.7: 27.42