HitPredict

Interactor 1: CASP3 (P70677)
Caspase-3 (CASP-3) (EC 3.4.22.56) (Apopain) (Cysteine protease CPP32) (CPP-32) (LICE) (Protein Yama) (SREBP cleavage activity 1) (SCA-1) [Cleaved into: Caspase-3 subunit p17; Caspase-3 subunit p12]
Gene: CASP3

Interactor 2: XIAP (Q60989)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP homolog A) (Inhibitor of apoptosis protein 3) (IAP-3) (mIAP-3) (mIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19626005
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	BIR~Peptidase_C14
Common GO terms	GO:0002020 - protease binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0006974 - DNA damage response GO:0043066 - negative regulation of apoptotic process and 1 others more... GO:0051402 - neuron apoptotic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 277 Mm			1 496
+	Hs
		788182 CASP3_HUMAN (1-277): 3.79e-130: 372: 86.64		XIAP_HUMAN (1-496): 0: 581: 89.14
+	Hs
		876939 CASP7_HUMAN (6-275): 1.23e-117: 341: 52.02		XIAP_HUMAN (1-496): 0: 581: 89.14
+	Mm
		957027 CASP7_MOUSE (26-275): 1.04e-115: 336: 55.34		XIAP_MOUSE (1-496): 0: 581: 100.00
+	Hs
		877014 CASP6_HUMAN (8-276): 1.92e-103: 304: 38.65		XIAP_HUMAN (1-496): 0: 581: 89.14
+	Hs
		957707 CASP8_HUMAN (4-275): 3.12e-97: 295: 35.27		XIAP_HUMAN (1-496): 0: 581: 89.14
+	Mm
		140026 CASP3_MOUSE (1-277): 2.5e-130: 372: 100.00		BIRC3_MOUSE (150-331): 3.72e-42: 160: 30.18
+	Hs
		788221 CASP3_HUMAN (1-277): 3.79e-130: 372: 86.64		BIRC7_HUMAN (14-155): 2.21e-33: 130: 23.78
+	Hs
		788230 CASP3_HUMAN (1-277): 3.79e-130: 372: 86.64		BIRC6_HUMAN (252-437): 1.81e-29: 125: 18.69
+	Hs
		788193 CASP3_HUMAN (1-277): 3.79e-130: 372: 86.64		BIRC3_HUMAN (398-496): 4.2e-24: 107: 41.41
+	Hs
		788194 CASP3_HUMAN (1-277): 3.79e-130: 372: 86.64		BIRC2_HUMAN (406-496): 9.26e-23: 103: 40.66
+	Hs
		876960 CASP7_HUMAN (6-275): 1.23e-117: 341: 52.02		BIRC7_HUMAN (14-155): 2.21e-33: 130: 23.78
+	Hs
		177658 CASP3_HUMAN (1-277): 3.79e-130: 372: 86.64		BIRC5_HUMAN (265-373): 6.39e-23: 96.5: 28.45
+	Hs
		876964 CASP7_HUMAN (6-275): 1.23e-117: 341: 52.02		BIRC6_HUMAN (252-437): 1.81e-29: 125: 18.69
+	Hs
		876944 CASP7_HUMAN (6-275): 1.23e-117: 341: 52.02		BIRC3_HUMAN (398-496): 4.2e-24: 107: 41.41
+	Hs
		876945 CASP7_HUMAN (6-275): 1.23e-117: 341: 52.02		BIRC2_HUMAN (406-496): 9.26e-23: 103: 40.66
+	Hs
		177663 CASP7_HUMAN (6-275): 1.23e-117: 341: 52.02		BIRC5_HUMAN (265-373): 6.39e-23: 96.5: 28.45
+	Hs
		1035745 CASP8_HUMAN (4-275): 3.12e-97: 295: 35.27		BIRC3_HUMAN (398-496): 4.2e-24: 107: 41.41
+	Dm
		136290 DRICE_DROME (36-275): 4.08e-100: 298: 41.63		DIAP2_DROME (13-140): 8.37e-21: 97.3: 22.66
+	Dm
		136289 DRICE_DROME (36-275): 4.08e-100: 298: 41.63		DIAP1_DROME (240-447): 8.54e-19: 90.8: 16.67
+	Dm
		137119 CASP1_DROME (7-275): 1.41e-99: 296: 36.13		DIAP1_DROME (240-447): 8.54e-19: 90.8: 16.67