Interactor 1: PSN1 (P97887)
Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]
Gene: Psen1

Interactor 2: Q5PQQ3 (Q5PQQ3)
Gamma-secretase subunit APH-1 (APH-1)
Gene: Aph1a

Species: Rattus norvegicus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.54 1.00 0.737

The method score is based on:

Property Details
Experiments 27036734, 12297508
Identification Methods anti bait coimmunoprecipitation
Interaction Type association, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains Aph-1~Presenilin
Common GO terms GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus
GO:0005886 - plasma membrane
GO:0006509 - membrane protein ectodomain proteolysis
and 11 others

more...

Homologous interactions 10

Homologous interactions

Color coding for hit scores

1 468
Rn

1 247
+ Mm
+ Hs
+ Mm
+ Hs
+ Hs
+ Mm
+ Hs
+ Dm
+ At
+ At

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Last updated: 15 Jul 2024