HitPredict

Interactor 1: DAB2 (P98078)
Disabled homolog 2 (Adaptor molecule disabled-2) (Differentially expressed in ovarian carcinoma 2) (DOC-2) (Mitogen-responsive phosphoprotein)
Gene: DAB2

Interactor 2: PARD3 (Q99NH2)
Partitioning defective 3 homolog (PAR-3) (PARD-3) (Atypical PKC isotype-specific-interacting protein) (ASIP) (Ephrin-interacting protein) (PHIP)
Gene: PARD3

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.646

Property	Details
Experiments	23354168
Identification Methods	pull down
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PDZ~PID
Common GO terms	GO:0002092 - positive regulation of receptor internalization GO:0005546 - phosphatidylinositol-4,5-bisphosphate binding GO:0005737 - cytoplasm GO:0016324 - apical plasma membrane GO:0035091 - phosphatidylinositol binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 766 Mm			1 1333
+	Hs
		833631 NUMB_HUMAN (26-678): 6e-47: 179: 14.24		PARD3_HUMAN (1-1333): 0: 700: 89.68
+	Dm
		561276 NUMB_DROME (24-531): 1.64e-38: 153: 11.91		Q0KHR3_DROME (42-1073): 1.39e-88: 319: 22.01
+	Dm
		332283 NUMB_DROME (24-531): 1.64e-38: 153: 11.91		O96782_DROME (1-1073): 7.69e-64: 241: 21.59
+	Hs
		833629 NUMB_HUMAN (26-678): 6e-47: 179: 14.24		LNX1_HUMAN (358-824): 1.33e-29: 129: 14.02
+	Mm
		1265184 NUMB_MOUSE (26-678): 7.52e-45: 173: 13.19		LNX2_MOUSE (438-742): 2.34e-29: 128: 17.26
+	Hs
		833625 NUMB_HUMAN (26-678): 6e-47: 179: 14.24		LNX2_HUMAN (25-356): 3.69e-26: 118: 12.50
+	Hs
		1252371 ANS1A_HUMAN (1-248): 2.57e-37: 152: 19.44		LNX1_HUMAN (358-824): 1.33e-29: 129: 14.02
+	Hs
		269170 DAB1_HUMAN (11-617): 1.62e-37: 150: 23.57		LNX1_HUMAN (358-824): 1.33e-29: 129: 14.02
+	Hs
		1252574 NUMBL_HUMAN (11-540): 1.78e-36: 147: 14.34		LNX1_HUMAN (358-824): 1.33e-29: 129: 14.02
+	Hs
		1115807 Q49AR9_HUMAN (1-280): 5.2e-36: 145: 17.87		LNX1_HUMAN (358-824): 1.33e-29: 129: 14.02
+	Mm
		250665 NUMB_MOUSE (26-678): 7.52e-45: 173: 13.19		LNX1_MOUSE (76-386): 1.87e-17: 90.1: 15.46
+	Hs
		1377729 NUMBL_HUMAN (11-540): 1.78e-36: 147: 14.34		GRIP1_HUMAN (225-1250): 6.67e-23: 108: 10.63
+	Mm
		1143409 Q8BZM2_MOUSE (2-228): 5.5e-45: 170: 18.18		DLG4_MOUSE (243-391): 7e-12: 72.3: 20.13
+	Mm
		1143393 ANS1B_MOUSE (2-231): 5.14e-41: 164: 17.95		DLG4_MOUSE (243-391): 7e-12: 72.3: 20.13
+	Rn
		957050 Q3MUI2_RAT (11-540): 6.99e-37: 149: 14.50		GRIP1_RAT (55-402): 3.9e-14: 79.7: 11.55
+	Mm
		887083 ANS1A_MOUSE (1-248): 1.21e-38: 156: 19.05		DLG4_MOUSE (243-391): 7e-12: 72.3: 20.13
+	Mm
		1143442 DP13A_MOUSE (20-249): 2.95e-38: 154: 14.17		DLG4_MOUSE (243-391): 7e-12: 72.3: 20.13
+	Hs
		942395 DP13A_HUMAN (20-242): 4.12e-37: 150: 12.45		DLG4_HUMAN (243-391): 7.49e-12: 71.9: 20.13
+	Mm
		1143503 CAPON_MOUSE (21-284): 6.38e-37: 147: 14.73		DLG4_MOUSE (243-391): 7e-12: 72.3: 20.13
+	Hs
		253559 CAPON_HUMAN (21-284): 6.11e-38: 150: 14.53		SCRIB_HUMAN (458-668): 7.93e-09: 62.4: 26.52