HitPredict - High confidence protein-protein interactions

Interactor 1: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Interactor 2: XIAP (P98170)
E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)
Gene: XIAP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.98	1.00	0.990

Property	Details
Experiments	19549727, 11724934, 18570872, 16189514, 25619915, 25801170, 27865841, 29053960, 27107012, 23166698, 30778852, 32788347, 34247143, 36243803, 21113135, 22825849, 11602612, 23259674, 16338389, 24975362 and 4 others more... 11927604, 14576775, 19273858, 31515488
Identification Methods	enzymatic study, two hybrid, x-ray crystallography, affinity chromatography technology, pull down, anti tag coimmunoprecipitation, surface plasmon resonance, barcode fusion genetics two hybrid, validated two hybrid, two hybrid array and 1 others more... two hybrid pooling approach
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	BIR~BIR, BIR~zf-C3HC4_3, zf-C3HC4_3~zf-C3HC4_3
Common GO terms	GO:0004842 - ubiquitin-protein transferase activity GO:0004869 - cysteine-type endopeptidase inhibitor activity GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm and 32 others more... GO:0005829 - cytosol GO:0006974 - DNA damage response GO:0010804 - negative regulation of tumor necrosis factor-mediated signaling pathway GO:0016055 - Wnt signaling pathway GO:0030510 - regulation of BMP signaling pathway GO:0031398 - positive regulation of protein ubiquitination GO:0032481 - positive regulation of type I interferon production GO:0042127 - regulation of cell population proliferation GO:0042742 - defense response to bacterium GO:0042981 - regulation of apoptotic process GO:0043027 - cysteine-type endopeptidase inhibitor activity involved in apoptotic process GO:0043066 - negative regulation of apoptotic process GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0043154 - negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0045088 - regulation of innate immune response GO:0046330 - positive regulation of JNK cascade GO:0046872 - metal ion binding GO:0050727 - regulation of inflammatory response GO:0051402 - neuron apoptotic process GO:0051726 - regulation of cell cycle GO:0055070 - copper ion homeostasis GO:0060785 - regulation of apoptosis involved in tissue homeostasis GO:0061135 - endopeptidase regulator activity GO:0061630 - ubiquitin protein ligase activity GO:0070424 - regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0070427 - nucleotide-binding oligomerization domain containing 1 signaling pathway GO:0070431 - nucleotide-binding oligomerization domain containing 2 signaling pathway GO:0070534 - protein K63-linked ubiquitination GO:0090263 - positive regulation of canonical Wnt signaling pathway GO:0097340 - inhibition of cysteine-type endopeptidase activity GO:0120283 - protein serine/threonine kinase binding GO:1902530 - positive regulation of protein linear polyubiquitination
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1	497
Hs

1	497

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Last updated: 15 Jul 2024