HitPredict

Interactor 1: RHOA (P61586)
Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12)
Gene: RHOA

Interactor 2: RHG07 (Q96QB1)
Rho GTPase-activating protein 7 (Deleted in liver cancer 1 protein) (DLC-1) (HP protein) (Rho-type GTPase-activating protein 7) (START domain-containing protein 12) (StARD12) (StAR-related lipid transfer protein 12)
Gene: DLC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	32203420
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ras~RhoGAP
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005925 - focal adhesion GO:0030036 - actin cytoskeleton organization GO:0032587 - ruffle membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 193 Hs			1 1528
+	Hs
		962328 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		STAR8_HUMAN (504-1526): 0: 598: 37.52
+	Hs
		74012 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MYO9A_HUMAN (278-1336): 3.01e-146: 499: 14.35
+	Hs
		962018 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		MYO9B_HUMAN (441-1383): 2.74e-102: 365: 14.00
+	Sc
		448535 RHO1_YEAST (3-188): 1.51e-97: 283: 73.12		RGA1_YEAST (733-1263): 2.35e-81: 292: 17.63
+	Hs
		962583 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG23_HUMAN (526-1349): 4.53e-87: 315: 14.05
+	Hs
		962142 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG21_HUMAN (326-1410): 5.61e-86: 313: 14.16
+	Hs
		962580 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		GMIP_HUMAN (603-1398): 1.04e-81: 293: 12.19
+	Hs
		260706 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		OPHN1_HUMAN (747-1431): 1.33e-82: 292: 12.60
+	Hs
		962215 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		SRGP1_HUMAN (899-1344): 3.14e-79: 287: 15.45
+	Hs
		962452 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG39_HUMAN (239-1286): 2.6e-79: 287: 13.19
+	Hs
		49960 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG10_HUMAN (747-1392): 7.59e-76: 271: 12.54
+	Hs
		962004 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG05_HUMAN (737-1270): 2.12e-72: 269: 14.72
+	Hs
		962536 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG35_HUMAN (808-1303): 3.6e-68: 256: 17.90
+	Sp
		207213 RHO1_SCHPO (1-193): 3.62e-94: 274: 66.83		RGA1_SCHPO (1034-1295): 1.22e-56: 217: 24.03
+	Hs
		962001 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		ABR_HUMAN (1013-1244): 2.65e-65: 241: 23.93
+	Hs
		539989 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		BCR_HUMAN (1046-1273): 1.18e-56: 218: 23.93
+	Hs
		962110 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHGBB_HUMAN (1075-1245): 1e-15: 80.9: 32.57
+	Mm
		1204453 RHOA_MOUSE (1-193): 2.21e-80: 238: 99.48		RHG01_MOUSE (1076-1234): 4.43e-14: 78.6: 31.06
+	Hs
		961987 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG01_HUMAN (1089-1234): 2.33e-13: 76.3: 30.82
+	Hs
		962107 RHOA_HUMAN (1-193): 7.2e-80: 237: 100.00		RHG31_HUMAN (1074-1234): 2.19e-12: 74.3: 31.52