HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: Q4LE69 (Q4LE69)
Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	-
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 192 Hs			1 2121
+	Hs
		581088 RAC2_HUMAN (1-192): 2.74e-81: 241: 92.19		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		1195694 RHOJ_HUMAN (2-189): 1.39e-80: 240: 60.64		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		953481 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		955244 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		1015487 RHOG_HUMAN (1-192): 1.18e-77: 231: 71.35		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		962117 RHOA_HUMAN (5-192): 1.33e-75: 226: 57.98		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		466292 RHOC_HUMAN (5-192): 3.53e-73: 220: 57.45		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		601315 RHOQ_HUMAN (4-190): 7.78e-73: 220: 63.16		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		135879 RAC2_HUMAN (1-192): 2.74e-81: 241: 92.19		P3C2A_HUMAN (1411-2120): 1.92e-150: 512: 17.85
+	Hs
		838980 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Hs
		135909 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		P3C2A_HUMAN (1411-2120): 1.92e-150: 512: 17.85
+	Hs
		135910 RHOA_HUMAN (5-192): 1.33e-75: 226: 57.98		P3C2A_HUMAN (1411-2120): 1.92e-150: 512: 17.85
+	Hs
		838973 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Hs
		601200 RHOQ_HUMAN (4-190): 7.78e-73: 220: 63.16		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Mm
		988901 RAC1_MOUSE (1-192): 4.32e-85: 250: 100.00		PK3CB_MOUSE (1465-2118): 2.74e-140: 468: 18.62
+	Mm
		953809 CDC42_MOUSE (1-192): 5.32e-78: 232: 70.31		PK3CB_MOUSE (1465-2118): 2.74e-140: 468: 18.62
+	Mm
		1015959 RHOG_MOUSE (1-192): 1.18e-77: 231: 71.35		PK3CB_MOUSE (1465-2118): 2.74e-140: 468: 18.62
+	Hs
		962282 RHOA_HUMAN (5-192): 1.33e-75: 226: 57.98		PK3C3_HUMAN (1415-2117): 8.9e-127: 424: 17.26