HitPredict

Interactor 1: RHOQ (P17081)
Rho-related GTP-binding protein RhoQ (Ras-like protein TC10) (Ras-like protein family member 7A)
Gene: RHOQ

Interactor 2: Q4LE69 (Q4LE69)
Phosphatidylinositol 4-kinase alpha (EC 2.7.1.67)
Gene: PIK4CA

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.80	0.553

Property	Details
Experiments	31871319
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PI3_PI4_kinase~Ras
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 205 Hs			1 2121
+	Hs
		1195694 RHOJ_HUMAN (9-204): 1.18e-108: 311: 79.59		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		988413 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		1015487 RHOG_HUMAN (9-199): 1.71e-77: 231: 54.97		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		581088 RAC2_HUMAN (10-196): 9.52e-77: 230: 62.03		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		962117 RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		953481 RAC3_HUMAN (10-183): 3.69e-76: 228: 66.67		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		955244 CDC42_HUMAN (9-193): 3.18e-75: 226: 67.57		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		978050 RHOB_HUMAN (1-204): 2.53e-75: 226: 49.51		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		466292 RHOC_HUMAN (1-192): 2.25e-74: 224: 50.52		Q4LE69_HUMAN (1-2121): 0: 2752: 100.00
+	Hs
		601200 RHOQ_HUMAN (1-205): 3.47e-83: 247: 100.00		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Hs
		135879 RAC2_HUMAN (10-196): 9.52e-77: 230: 62.03		P3C2A_HUMAN (1411-2120): 1.92e-150: 512: 17.85
+	Hs
		135910 RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75		P3C2A_HUMAN (1411-2120): 1.92e-150: 512: 17.85
+	Hs
		838980 RAC1_HUMAN (10-195): 2.03e-80: 239: 63.98		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Hs
		135909 CDC42_HUMAN (9-193): 3.18e-75: 226: 67.57		P3C2A_HUMAN (1411-2120): 1.92e-150: 512: 17.85
+	Hs
		838973 RAC3_HUMAN (10-183): 3.69e-76: 228: 66.67		PK3CA_HUMAN (1461-2117): 1.73e-151: 500: 21.77
+	Mm
		988901 RAC1_MOUSE (10-195): 2.03e-80: 239: 63.98		PK3CB_MOUSE (1465-2118): 2.74e-140: 468: 18.62
+	Mm
		1015959 RHOG_MOUSE (9-199): 1.71e-77: 231: 54.97		PK3CB_MOUSE (1465-2118): 2.74e-140: 468: 18.62
+	Mm
		953809 CDC42_MOUSE (9-193): 3.18e-75: 226: 67.57		PK3CB_MOUSE (1465-2118): 2.74e-140: 468: 18.62
+	Hs
		962282 RHOA_HUMAN (1-201): 1.72e-76: 229: 49.75		PK3C3_HUMAN (1415-2117): 8.9e-127: 424: 17.26