HitPredict

Interactor 1: DCA11 (P90794)
DDB1- and CUL4-associated factor 11 homolog (WD repeat-containing protein 23)
Gene: wdr-23

Interactor 2: DDB1 (Q21554)
DNA damage-binding protein 1 (Damage-specific DNA-binding protein 1)
Gene: ddb-1

Species: Caenorhabditis elegans

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	19273594
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	CPSF_A~WD40, MMS1_N~WD40
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 571 Ce			1 1134
+	Hs
		1082374 TBL1R_HUMAN (8-343): 9.63e-47: 173: 10.98		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Hs
		1016284 TBL3_HUMAN (171-570): 5.58e-45: 172: 11.48		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Hs
		245605 TBL1X_HUMAN (11-343): 3.57e-45: 170: 10.50		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Hs
		903254 WDR5_HUMAN (396-571): 4.63e-37: 142: 14.89		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Hs
		1082263 WDR5B_HUMAN (395-571): 2.2e-34: 134: 16.32		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Mm
		1112307 SKI8_MOUSE (270-512): 1.94e-17: 85.3: 16.50		DDB1_MOUSE (1-1134): 0: 1212: 36.43
+	Hs
		1082460 FBW1A_HUMAN (300-517): 2.49e-17: 87.6: 18.55		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Hs
		1082295 DCA11_HUMAN (367-543): 2.52e-17: 87.3: 16.75		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Hs
		1082381 SKI8_HUMAN (161-512): 1.38e-17: 85.6: 15.01		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	Hs
		1073168 NLE1_HUMAN (22-469): 1.27e-76: 252: 11.40		SF3B3_HUMAN (3-1130): 0: 1033: 18.17
+	Mm
		1112291 DCA11_MOUSE (88-278): 2.1e-10: 65.3: 8.75		DDB1_MOUSE (1-1134): 0: 1212: 36.43
+	Hs
		1082327 SNR40_HUMAN (476-567): 5.14e-10: 63.4: 13.46		DDB1_HUMAN (1-1134): 0: 1209: 36.43
+	At
		1228206 Q8LPI5_ARATH (223-529): 6.6e-23: 104: 11.95		DDB1A_ARATH (2-1134): 0: 1154: 32.70
+	At
		1340746 VIP3_ARATH (271-419): 8.01e-10: 62.4: 29.41		DDB1A_ARATH (2-1134): 0: 1154: 32.70
+	At
		221835 VIP3_ARATH (271-419): 8.01e-10: 62.4: 29.41		DDB1B_ARATH (3-1134): 0: 1141: 32.64
+	Hs
		1073192 FBW1A_HUMAN (300-517): 2.49e-17: 87.6: 18.55		SF3B3_HUMAN (3-1130): 0: 1033: 18.17
+	Hs
		1073144 SKI8_HUMAN (161-512): 1.38e-17: 85.6: 15.01		SF3B3_HUMAN (3-1130): 0: 1033: 18.17
+	Hs
		1014208 NLE1_HUMAN (22-469): 1.27e-76: 252: 11.40		CPSF1_HUMAN (4-544): 1.85e-122: 412: 15.98
+	Hs
		197009 PRP4_HUMAN (311-571): 1.33e-45: 170: 16.14		CPSF1_HUMAN (4-544): 1.85e-122: 412: 15.98
+	Hs
		1014128 TAF5_HUMAN (116-450): 2.33e-26: 116: 17.09		CPSF1_HUMAN (4-544): 1.85e-122: 412: 15.98