HitPredict

Interactor 1: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Interactor 2: ARHGJ (Q8IW93)
Rho guanine nucleotide exchange factor 19 (Ephexin-2)
Gene: ARHGEF19

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	18256687
Identification Methods	pull down
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Ras~RhoGEF
Common GO terms	GO:0005829 - cytosol GO:0032956 - regulation of actin cytoskeleton organization GO:0060071 - Wnt signaling pathway, planar cell polarity pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 192 Hs			1 802
+	Hs
		988526 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		NGEF_HUMAN (123-790): 6.12e-125: 392: 31.82
+	Hs
		988602 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		ARHGQ_HUMAN (5-792): 2.79e-118: 380: 25.46
+	Hs
		988618 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		SPT13_HUMAN (190-711): 4.41e-107: 344: 13.25
+	Hs
		988741 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		ARHG4_HUMAN (104-749): 2.28e-105: 340: 13.39
+	Hs
		988854 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		FARP1_HUMAN (153-735): 8.48e-93: 315: 16.64
+	Hs
		584511 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		VAV_HUMAN (268-737): 5.69e-93: 311: 15.32
+	Hs
		988716 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		ECT2_HUMAN (237-801): 3.61e-92: 311: 18.01
+	Hs
		581392 RAC2_HUMAN (1-192): 2.74e-81: 241: 92.19		FARP1_HUMAN (153-735): 8.48e-93: 315: 16.64
+	Hs
		1433596 RHOJ_HUMAN (2-189): 1.39e-80: 240: 60.64		FARP1_HUMAN (153-735): 8.48e-93: 315: 16.64
+	Hs
		165458 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		RGRF2_HUMAN (204-750): 5.36e-88: 304: 13.49
+	Hs
		213355 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		ARHG9_HUMAN (301-742): 8.41e-100: 320: 13.78
+	Hs
		953776 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		FARP1_HUMAN (153-735): 8.48e-93: 315: 16.64
+	Hs
		953715 RAC3_HUMAN (1-191): 3.71e-78: 233: 93.19		ARHGC_HUMAN (154-750): 3.59e-88: 307: 13.74
+	Hs
		165455 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		RGRF2_HUMAN (204-750): 5.36e-88: 304: 13.49
+	Dm
		828016 RAC1_DROME (1-192): 8.88e-82: 242: 91.67		Q9U7D8_DROME (382-732): 5.17e-86: 293: 20.88
+	Dm
		874080 RAC2_DROME (1-192): 1.86e-80: 239: 89.58		Q9U7D8_DROME (382-732): 5.17e-86: 293: 20.88
+	Sp
		1029426 CDC42_SCHPO (1-192): 9.24e-81: 240: 68.23		RGF1_SCHPO (332-699): 3.39e-74: 265: 20.60
+	Hs
		238812 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		KALRN_HUMAN (360-801): 2.7e-69: 252: 14.38
+	Hs
		177376 RAC1_HUMAN (1-192): 4.32e-85: 250: 100.00		ARHGB_HUMAN (355-704): 4.94e-64: 235: 19.89
+	Hs
		177372 CDC42_HUMAN (1-192): 5.32e-78: 232: 70.31		ARHGB_HUMAN (355-704): 4.94e-64: 235: 19.89