HitPredict

Interactor 1: CANB1 (P63098)
Calcineurin subunit B type 1 (Protein phosphatase 2B regulatory subunit 1) (Protein phosphatase 3 regulatory subunit B alpha isoform 1)
Gene: PPP3R1

Interactor 2: PP2BA (Q08209)
Protein phosphatase 3 catalytic subunit alpha (EC 3.1.3.16) (CAM-PRP catalytic subunit) (Calcineurin A alpha) (Calmodulin-dependent calcineurin A subunit alpha isoform) (CNA alpha) (Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform)
Gene: PPP3CA

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.97 1.00 0.988

The method score is based on:

Property Details
Experiments 25416956, 26186194, 21516116, 27880917, 28514442, 26871637, 32296183, 26264872, 33961781, 28524877, 23468591, 22343722, 24954618, 8524402, unassigned1304, 32814053, 19896943
Identification Methods two hybrid, affinity chromatography technology, cross-linking study, molecular sieving, pull down, light scattering, two hybrid prey pooling approach, two hybrid array, validated two hybrid, x-ray crystallography and 2 others

more...
Interaction Type direct interaction, physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains EF-hand_7~Metallophos
Common GO terms GO:0005509 - calcium ion binding
GO:0005516 - calmodulin binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0005955 - calcineurin complex
and 11 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 170
Hs

1 521
+ Rn
+ Hs
+ Mm
+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Dm
+ Ce
+ Dm
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
+ Sc
+ Sc
+ Dd
+ Dm

Service provided by Combinatics, Japan

Last updated: 11Aug2025