Protein: MED10
Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20)

Gene: MED10
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q9BTT4

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003712 - transcription coregulator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0016567 - protein ubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

206645

MED7
Mediator of RNA polymerase II transcription subunit 7

10

6

Small-scale

0.975

High

270526

MED6
Mediator of RNA polymerase II transcription subunit 6

8

4

Small-scale

0.970

High

1037090

MED21
Mediator of RNA polymerase II transcription subunit 21

7

1

Small-scale

0.967

High

225414

MED14
Mediator of RNA polymerase II transcription subunit 14

7

4

Small-scale

0.962

High

48718

MED19
Mediator of RNA polymerase II transcription subunit 19

11

0

Small-scale

0.929

High

826345

CDK8
Cyclin-dependent kinase 8

13

3

Small-scale

0.761

High

1312299

MED17
Mediator of RNA polymerase II transcription subunit 17

11

1

Small-scale

0.760

High

1312292

MED18
Mediator of RNA polymerase II transcription subunit 18

10

1

Small-scale

0.759

High

1291841

MED8
Mediator of RNA polymerase II transcription subunit 8

9

1

Small-scale

0.757

High

1274339

MED12
Mediator of RNA polymerase II transcription subunit 12

10

1

Small-scale

0.755

High

1312296

MED20
Mediator of RNA polymerase II transcription subunit 20

9

1

Small-scale

0.755

High

1312304

MED11
Mediator of RNA polymerase II transcription subunit 11

8

1

Small-scale

0.754

High

1312297

MED4
Mediator of RNA polymerase II transcription subunit 4

8

1

Small-scale

0.752

High

624499

CCNC
Cyclin-C

8

2

Small-scale

0.750

High

1312308

MED13
Mediator of RNA polymerase II transcription subunit 13

8

1

Small-scale

0.749

High

1312310

MED16
Mediator of RNA polymerase II transcription subunit 16

7

1

Small-scale

0.745

High

1312302

MED29
Mediator of RNA polymerase II transcription subunit 29

6

1

Small-scale

0.738

High

1312312

MED31
Mediator of RNA polymerase II transcription subunit 31

6

1

Small-scale

0.738

High

1293697

MED30
Mediator of RNA polymerase II transcription subunit 30

6

1

Small-scale

0.735

High

1158919

MED27
Mediator of RNA polymerase II transcription subunit 27

6

1

Small-scale

0.732

High

1312309

MED23
Mediator of RNA polymerase II transcription subunit 23

6

1

Small-scale

0.732

High

1312293

CDK19
Cyclin-dependent kinase 19

6

3

High-throughput

0.729

High

1076196

MED1
Mediator of RNA polymerase II transcription subunit 1

9

0

Small-scale

0.722

High

1074724

MED22
Mediator of RNA polymerase II transcription subunit 22

8

0

Small-scale

0.717

High

265358

MED24
Mediator of RNA polymerase II transcription subunit 24

8

0

Small-scale

0.717

High

1174774

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

5

1

Small-scale

0.716

High

1174958

MED25
Mediator of RNA polymerase II transcription subunit 25

5

1

Small-scale

0.716

High

313462

MED26
Mediator of RNA polymerase II transcription subunit 26

7

0

Small-scale

0.716

High

1312301

MED9
Mediator of RNA polymerase II transcription subunit 9

6

0

Small-scale

0.701

High

1301087

MED15
Mediator of RNA polymerase II transcription subunit 15

4

2

Small-scale

0.694

High

1312294

MED28
Mediator of RNA polymerase II transcription subunit 28

5

0

High-throughput

0.688

High

583566

RPB3
DNA-directed RNA polymerase II subunit RPB3

3

1

High-throughput

0.667

High

181450

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

0

High-throughput

0.646

High

583782

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

0

High-throughput

0.646

High

625017

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

High-throughput

0.638

High

676985

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

0

High-throughput

0.638

High

1206156

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

2

1

High-throughput

0.611

High

177718

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

738875

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

0

High-throughput

0.585

High

854355

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

2

0

High-throughput

0.585

High

854459

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

0

High-throughput

0.585

High

864977

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

0

High-throughput

0.585

High

897616

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

2

0

High-throughput

0.585

High

913945

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.585

High

921157

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

0

High-throughput

0.585

High

1281354

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.585

High

1312295

TRI45
E3 ubiquitin-protein ligase TRIM45

2

0

High-throughput

0.580

High

1312303

ABI2
Abl interactor 2

2

0

High-throughput

0.580

High

475171

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

0

High-throughput

0.576

High

295552

RECQ5
ATP-dependent DNA helicase Q5

2

1

High-throughput

0.571

High

370335

ESR1
Estrogen receptor

1

3

Small-scale

0.561

High

1312291

MED10
Mediator of RNA polymerase II transcription subunit 10

2

1

Small-scale

0.552

High

1087379

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.536

High

1205514

PTOV1
Prostate tumor-overexpressed gene 1 protein

1

1

High-throughput

0.536

High

509110

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

1160889

FXL19
F-box/LRR-repeat protein 19

1

0

High-throughput

0.513

High

1307105

H2A1J
Histone H2A type 1-J

1

0

High-throughput

0.513

High

782647

HNF4A
Hepatocyte nuclear factor 4-alpha

1

2

Small-scale

0.501

High

1269492

ESR2
Estrogen receptor beta

1

3

Small-scale

0.501

High

876883

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.486

High

244873

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

487730

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

1019113

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1067115

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1137945

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

2

High-throughput

0.479

High

1298984

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

3

High-throughput

0.479

High

1312298

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

1

3

High-throughput

0.479

High

246610

MCE1
mRNA-capping enzyme

1

0

High-throughput

0.458

High

304652

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

319991

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

325360

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

347763

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

501086

IRF1
Interferon regulatory factor 1

1

0

Small-scale

0.458

High

917848

H4
Histone H4

1

0

High-throughput

0.458

High

1076286

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

1173759

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.458

High

1221353

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1299675

QKI
KH domain-containing RNA-binding protein QKI

1

0

High-throughput

0.458

High

1306528

EPAS1
Endothelial PAS domain-containing protein 1

1

0

Small-scale

0.458

High

73039

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91308

E5RFK5
Cyclin-C

1

2

High-throughput

0.445

High

130170

ELL2
RNA polymerase II elongation factor ELL2

1

1

High-throughput

0.445

High

301158

KDM4B
Lysine-specific demethylase 4B

1

0

High-throughput

0.438

High

671695

PEBP1
Phosphatidylethanolamine-binding protein 1

1

0

High-throughput

0.438

High

1146795

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

134187

DDX3X
ATP-dependent RNA helicase DDX3X

1

0

High-throughput

0.426

High

418602

NPM
Nucleophosmin

1

0

High-throughput

0.426

High

643584

PTBP1
Polypyrimidine tract-binding protein 1

1

0

High-throughput

0.426

High

714060

HS71L
Heat shock 70 kDa protein 1-like

1

0

High-throughput

0.426

High

932845

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.426

High

1025937

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.426

High

1054549

RBM39
RNA-binding protein 39

1

0

High-throughput

0.426

High

1069780

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.426

High

1220149

CCAR1
Cell division cycle and apoptosis regulator protein 1

1

0

High-throughput

0.426

High

1312305

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.426

High

1312306

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.426

High

1312307

AFF4
AF4/FMR2 family member 4

1

0

High-throughput

0.426

High

831653

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

329043

TCL1B
T-cell leukemia/lymphoma protein 1B

3

0

High-throughput

0.347

High

375819

FUCO
Tissue alpha-L-fucosidase

2

0

High-throughput

0.316

High

1306624

GDIR3
Rho GDP-dissociation inhibitor 3

2

0

High-throughput

0.316

High

1312311

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.282

High

1164366

POTEE
POTE ankyrin domain family member E

1

0

High-throughput

0.279

Low

67711

SYC1L
Synaptonemal complex central element protein 1-like

1

0

High-throughput

0.251

Low

361604

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.249

Low

1150686

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

473918

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low

892890

IF4A1
Eukaryotic initiation factor 4A-I

1

0

High-throughput

0.232

Low

1264795

TITIN
Titin

1

0

High-throughput

0.232

Low

1312300

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024